AIDS Increases Risk of Stomach, Esophageal Cancers

Among people with AIDS, the risk of stomach and esophageal malignancies is higher than among the general population.

Among people with AIDS, the risk of stomach and esophageal malignancies is higher than among the general population, according to study results presented at the AACR 102nd Annual Meeting 2011.

"People diagnosed with AIDS are living longer due to improved therapies. However, they are at increased risk of developing a number of different cancers, including Kaposi's sarcoma and several lymphomas. The risk of stomach and esophageal cancers in AIDS patients has not previously been fully evaluated," said E. Christina Persson, Ph.D., a postdoctoral fellow at the National Cancer Institute.

Quiz on HIV / AIDS
Statistics tell us that the world HIV+ population has risen drastically from 8 million in 1990 to a whopping 33 million in 2007! Even more alarming is the fact that young people (below the age of 25) account for half of these infections! This is adequate proof for the lack of awareness among the general public even in these modern times. So take our quiz and brush up on the essential facts of HIV/AIDS.

There are 10 questions on HIV / AIDS in this quiz that will explore the depth of your knowledge and provide answers to the following:

Immune control of HIV ()
Symptoms of HIV/AIDS ()
Cure for AIDS ()
Acute HIV syndrome ()
World AIDS day ()
Western blot ()

Persson and colleagues utilized data from the HIV/AIDS Cancer Match Study, a linkage of 15 U.S. population-based HIV/AIDS and cancer registries with data from 1980 through 2007. The study included 600,000 men and women diagnosed with AIDS, of whom 1,166 developed stomach malignancies and 240 developed esophageal malignancies.

Overall, people with AIDS had a 6.9-fold increased incidence of stomach malignancies compared to the general population. The risk was increased 70 percent for stomach carcinomas, with similar increases for proximal (cardia) and distal (non-cardia) carcinomas. The risk for stomach lymphomas was 36-fold higher.

The overall risk of esophageal malignancies was 2.7 times higher among people with AIDS than in the general population. Risk was increased 54 percent for squamous cell carcinomas, 101 percent for adenocarcinomas, and 261-fold for lymphomas of the esophagus.

Persson said that the increased lymphoma risk among patients with AIDS was expected, but the increased risk for carcinomas is a new finding. Additionally, the size of this study allowed the researchers to look at carcinoma subtypes.

Oesophageal atresia / Tracheo oesophageal fistula (TOF)
Oesophageal atresia is blockage in the oesophagus (food pipe). It is often associated with an abnormal connection between the oesophagus and trachea (wind pipe) below the level of blockage.

"This study is unique because of its large size, which allowed us to look more closely at the different histologic and anatomic subsites of the tumors," said Persson. "It will be important for us to evaluate trends in risk over time, particularly in the modern HIV treatment era."

Source-Eurekalert

The Splendid Stomach
Stomach is the organ where food is mixed, stored and partially digested.