Alirocumab Cuts Apheresis Rates in Familial Hypercholesterolemia Patients

Patients who have heterozygous familial hypercholesterolemia can reduce or even eliminate their need for expensive and time-consuming apheresis treatments.

Heterozygous familial hypercholesterolemia (HeFH) is a condition that causes abnormally raised low-density lipoprotein cholesterol (LDL-C) levels and premature cardiovascular disease.

Patients who have heterozygous familial hypercholesterolemia (HeFH) can significantly reduce or even eliminate their need for expensive and time-consuming apheresis treatments with the PCSK9 inhibitor alirocumab.

Alirocumab Shows Promise as Treatment to Lower LDL-Cholesterol
A clinical trial report reviewing the first completed Phase III study in the ODYSSEY development program has shown that alirocumab showed significantly better LDL-C lowering than ezetimibe, with a comparable safety profile to ezetimibe.

‘In the overall management of patients with HeFH undergoing regular lipoprotein apheresis therapy, alirocumab has the potential to avoid apheresis treatments.’

Results of the phase 3 ODYSSEY-ESCAPE trial, reported in a Hot Line session at ESC Congress 2016, "suggest a role for alirocumab in the overall management of patients with HeFH undergoing regular lipoprotein apheresis therapy, with the potential to avoid apheresis treatments or delay the requirement for such treatments," said the study's lead investigator Patrick M. Moriarty, MD, from the University of Kansas Medical Center, in Kansas City, KS, USA.

The findings, published simultaneously in The European Heart Journal, have exciting implications for HeFH patients, many of whom struggle with weekly apheresis treatments, he explained.

"Being able to reduce or eliminate apheresis would be a major breakthrough for these patients who spend $50,000 to $75,000 a year, and 3-4 hours every 1-2 weeks to clear their blood of excess LDL-C. If our results are confirmed in other studies this could mark a new era for patients with familial hypercholesterolemia who have uncontrolled cholesterol levels and resistance to normal medical management."

Added Benefit of Alirocumab in Hypercholesterolaemia Not Proven
In patients for whom statin treatment is not an option, the drug alirocumab was to be compared with a different lipid-lowering drug as monotherapy.

The study included 62 HeFH patients from 14 centers in the US and Germany, who were undergoing apheresis either weekly or every 2 weeks. They were randomized to receive subcutaneous injections of either alirocumab 150 mg (n=41) or placebo (n=21) every 2 weeks for 18 weeks while still continuing their regular lipid-lowering medications (LLT).

Apheresis treatments during the study were scheduled over 2 phases:

Novel Antibody 'Alirocumab' can Lower 'Bad' Cholesterol in Patients
Adding alirocumab to statins in patients with heterozygous familial hypercholesterolemia rapidly lowers lipoprotein cholesterol (LDL-C) to unprecedented levels.

Until week 6, the rate was fixed according to the patient's established schedule, but was then adjusted between weeks 7 through 18 based on individual needs. If a patient's LDL-C had dropped by 30% or more since the start of the study, apheresis was skipped.

At the end of the study, the alirocumab-treated patients had a 75% greater reduction in apheresis compared to those on placebo. (P<0.0001). In fact, 63.4% of patients on alirocumab eliminated apheresis altogether (compared to none in the placebo group), and 92.7% avoided at least half of the procedures (compared to 14.3% in the placebo arm).

Why Genes May Not be Blamed for High Cholesterol Levels
Low-density lipoprotein (LDL) cholesterol levels is widely known as bad cholesterol because it leads to buildup of harmful plaque in the arteries.

"Reasons why apheresis rates reduced with placebo are unclear, but may reflect individual variation in LDL-C values, perhaps due to changes in diet or adherence to LLT, the small sample size, and the fact that patients were in a supervised clinical trial," noted Dr. Moriarty. Adverse events were generally not serious, and were similar in both groups (75.6% of alirocumab vs 76.2% of placebo patients).

"In the future, lipoprotein-apheresis centers may now add alirocumab to a patient's LLT and possibly not have to treat them with apheresis or at least treat them less often," predicted Dr. Moriarty. "Since the drug has already been approved for this patient population (HeFH and high CVD risk) it can be now considered part of standard care for these patients intolerant to other LLT. Both patients and health care providers will all be pleased to know there is potentially easier, more efficient, and less expensive means of treating dyslipidemia in these patients."

Source-Medindia