Alternative Drugs to Battle Antibiotic-Immune Pathogens on the Anvil

It is well-known that the indiscriminate use of antibiotics has allowed an increasing number of pathogens to develop immunity to penicillin and other antibiotics.

The threat is evident from the World Health Organization warning that if measures are not taken quickly, it may soon not be possible to treat many frequently occurring infections.

Drug Resistance – Antibiotic or Antimicrobial Resistance
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and hospital acquired diseases. Judicious use of antibiotics can control the problem.

But research scientists at the Fraunhofer Institute for Cell Therapy and Immunology IZI say they've found an alternative in the nick of time - antimicrobial peptides.

"We have already identified 20 of these short chains of amino acids which kill numerous microbes, including enterococci, yeasts and molds, as well as human pathogenic bacteria such as Streptococcus mutans, which is found in the human oral cavity and causes tooth decay," said Dr. Andreas Schubert, group manager at Fraunhofer IZI..

Even the multi-resistant hospital bug Staphylococcus aureus is not immune, and in our tests its growth was considerably inhibited," Schubert, said.

About Mosquito Diseases
Mosquito-borne diseases, like malaria, filaria, dengue, etc are common in places conducive of mosquito breeding. Swamps, ponds and stagnated drainage provide optimal breeding ground for mosquitoes.

From familiar fungicidal and bactericidal peptides the research scientists produced sequence variations and tested them in vitro on various microbes.

They then compared the survivability of the pathogens with an untreated control.

Metabolic Syndrome - About
Metabolic Syndrome is associated with sedentary lifestyle .It makes a person more prone to develop type 2 diabetes and coronary artery disease.

Antibiotic peptides unblock their microbicidal effect within a few minutes, stated Schubert, and work at a concentration of less than 1uM. Conventional antibiotics require a concentration of 10uM.

"The spectrum of efficacy of the tested peptides includes not only bacteria and molds but also lipid-enveloped viruses," Schubert added. "Another key factor is that the peptides identified in our tests do not harm healthy body cells."

Source-ANI