Alzheimer’s Disease Plays an Unfair Game

Prevention of Alzheimer’s disease (AD) has gender indifference as per a study conducted at the Florida Atlantic University published in The Journal of Prevention of Alzheimer s Disease. Almost two-thirds of patients with AD are females. Hence, gender becomes the most significant risk factor for AD as age advances.

Women are prone to twice the risk of developing AD, despite justification of gender-dependent mortality rates, age at death, and differences in lifespan.

Sex Differences May Affect Alzheimer’s Outcomes

The study thereby evaluated the role of gender differences in outcomes of tailored AD clinical interventions. The team also explored the influence of gender differences on the risk of developing cardiovascular disease and AD, along with blood markers of AD risk.

Data were analyzed from the Comparative Effectiveness Dementia & Alzheimer’s Registry (CEDAR) trial (launched at Weill Medicine in 2015).

“While care in an Alzheimer’s Prevention Clinic setting is equally effective at improving cognitive function in both women and men, our personally-tailored interventions led to greater improvements in women compared to men across Alzheimer’s and cardiovascular disease risk scales, as well blood biomarkers of risk such as blood sugar, LDL cholesterol, and the diabetes test HbA1C,” says Isaacson.

“Our findings are important because women are disproportionately affected by Alzheimer’s disease and population-attributable risk models suggest that managing risk factors can prevent up to one-third of dementia cases, highlighting the immense potential that lies in addressing modifiable risk factors,” says Isaacson.

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Source-Medindia