Anti-Obesity Drugs' Impact on Osteoarthritis Survival

For individuals grappling with knee or hip osteoarthritis alongside overweight or obesity, a gradual, not rapid, reduction in weight through anti-obesity medications might reduce their chances of early mortality, stated research published in //Arthritis & Rheumatology. (1^✔ ✔Trusted Source
Weight loss induced by anti-obesity medications and allcause mortality among patients with knee or hip osteoarthritis

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Effects of Anti-Obesity Meds on Mortality in Knee/Hip Osteoarthritis

Among 6,524 participants with knee or hip osteoarthritis who were taking orlistat, sibutramine, or rimonabant, the 5-year death rate was 5.3%, 4.0%, and 5.4% for the “weight gain/stable”, “slow-to-moderate weight loss,” and “fast weight loss” groups, respectively. Compared with the “weight gain/stable” group,” the risk of death was 28% lower for the “slow-to-moderate weight loss” group and only 1% lower for the “fast weight loss” arm.

"A slow-to-moderate rate of weight loss induced by anti-obesity medications may lower the risk of death in overweight/obese people with knee/hip osteoarthritis", said first author Jie Wei, PhD, of Xiangya Hospital, Central South University, in China.

Reference:

1. Weight loss induced by anti-obesity medications and allcause mortality among patients with knee or hip osteoarthritis - (https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/art.42754)

Source-Eurekalert