Preoperative antibiotic therapy administered within two hours of cardiac surgery decreased the risk of developing surgical site infections (SSIs) significantly, finds a new study.
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Dr. Finkelstein and his colleagues at Rambam Medical Center in Israel implemented a 10-year prospective cohort study emphasizing an optimized policy for preoperative antibiotic prophylaxis in cardiac surgery that included administering the first dose of antibiotic prophylaxis up to two hours before the first surgical incision. Prophylaxis given at a different time ranged in administration of three hours before to after the surgery.
SSIs were significantly less common among patients who received prophylaxis during the optimized period than patients who received antibiotic prophylaxis at a different time. Of the 2,637 patients included in the study, 8.3 percent (206 patients of 2,536) who received preoperative antibiotics within a two-hour window of the first incision developed an SSI, compared with 13.9 percent (14 patients of 101) of patients who received antibiotic prophylaxis at a different time. Additionally, in the last two years of the study near complete compliance of optimized administration of preoperative antibiotics was achieved.
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Source-Eurekalert
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