The use of biodegradable “nanoscavengers” to restore insulin sensitivity and treat type 2 diabetes has been discovered.
Biodegradable Hollow Nanoscavengers Restore Liver Functions to Reverse Insulin Resistance in Type 2 Diabetes
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How Does Type 2 Diabetes Occurs
Type 2 diabetes occurs when the body is no longer sensitive to insulin, which //regulates blood sugar. Currently, no cure exists, and available treatments focus on managing symptoms and blood sugar levels. Some research has suggested that insulin resistance could be caused by reactive oxygen species (ROS), which are highly unstable, oxygen-based molecules primarily produced by the mitochondria, or the “powerhouses of the cell.” A class of drugs known as mitochondrial uncouplers could help inhibit ROS production at its source, rather than merely cleaning up what’s already been made, as conventional, antioxidant-based treatments do. Ultrasmall platinum nanoparticles are another highly efficient ROS scavenger, though their small size causes them to be cleared from the liver too quickly.
Type 2 Diabetes - Risk Factors - Symptoms & Signs - Management - Prevention
Globalization and changing lifestyles has made diabetes very common in developing countries so much so that India is known as the Diabetes Capital of the World.
Globalization and changing lifestyles has made diabetes very common in developing countries so much so that India is known as the Diabetes Capital of the World.
‘Nanoscavengers when injected into the diabetic mice, migrated to the liver, lowering fat content and returning blood glucose levels to normal.’
But, by combining these two strategies into an all-in-one system, a highly effective and long-lasting treatment platform could be created.
To build the nanoscavengers, the team coated a template with platinum nanoparticles and a layer of silica. Then, the template was removed to form hollow shells, which were loaded with a mitochondrial uncoupler and coated with a lipid bilayer. When mixed with two ROS, hydrogen peroxide (H2O2) and superoxide (O2-), the system reduced them to water and molecular oxygen. In experiments using human liver cells with induced type 2 diabetes, the nanoscavengers continued to clean up ROS, as well as increase glucose uptake, suggesting that the cells’ insulin sensitivity was restored. The researchers then injected nanoscavengers intravenously into a diabetic mouse model.
Symptoms of diabetic nephropathy were reversed nearly completely. The mice showed no signs of body weight changes or damage to their tissues or organs. The researchers say that this work could provide an effective strategy for long-term treatment of diabetes and other metabolic diseases.
Quiz on Diabetes and Oral Health
Did you know that your dentist can identify signs of diabetes by just taking a peek in your mouth?
Everyone should maintain good oral health, but those with high blood sugar are more susceptible to developing oral health issues. Maintaining good oral hygiene and health is crucial for overall health and wellbeing. Good oral hygiene practices can aid in preventing tooth and gum diseases, discomfort, and infections ().
High blood sugar can decrease the salivary flow which is important to wash away the food particles that can lead to cavity formation ().
The quiz on Diabetes and Oral Health can be used by adults to familiarize them with some interesting information.
Did you know that your dentist can identify signs of diabetes by just taking a peek in your mouth?
Everyone should maintain good oral health, but those with high blood sugar are more susceptible to developing oral health issues. Maintaining good oral hygiene and health is crucial for overall health and wellbeing. Good oral hygiene practices can aid in preventing tooth and gum diseases, discomfort, and infections ().
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High blood sugar can decrease the salivary flow which is important to wash away the food particles that can lead to cavity formation ().
The quiz on Diabetes and Oral Health can be used by adults to familiarize them with some interesting information.
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- Biodegradable Hollow Nanoscavengers Restore Liver Functions to Reverse Insulin Resistance in Type 2 Diabetes - (https://pubs.acs.org/doi/10.1021/acsnano.3c00875)
Top Ten Facts About Diabetes
Diabetes or diabetes mellitus, is an endocrine and metabolic disorder characterized by high blood sugar levels (hyperglycemia) over a prolonged period of time.
Diabetes or diabetes mellitus, is an endocrine and metabolic disorder characterized by high blood sugar levels (hyperglycemia) over a prolonged period of time.
Insulin Injections for Diabetes
Insulin Therapy plays an important role in treating diabetes.Learning about insulin injections can help you better manage your diabetes condition.
Insulin Therapy plays an important role in treating diabetes.Learning about insulin injections can help you better manage your diabetes condition.
