Increased cardiovascular risk were observed in drugs combinations such celecoxib with mefenamic acid when compared to celecoxib with diclofenac, ibuprofen, or naproxen finds a new study.
Survival Rate of Colorectal Cancer Patients Improved With NSAIDs
Use of NSAIDs,or nonsteroidal anti-inflammatory drugs,is associated with 25 per cent reduction in all-cause mortality among long-term colorectal cancer survivors
Use of NSAIDs,or nonsteroidal anti-inflammatory drugs,is associated with 25 per cent reduction in all-cause mortality among long-term colorectal cancer survivors
‘Celecoxib with mefenamic acid was the only NSAID or painkiller found to increase heart risk when compared to other drug combinations significantly.’
The study also found no apparent difference in cardiovascular risk when comparing celecoxib with diclofenac, ibuprofen, or naproxen, although a significantly increased risk was observed when comparing celecoxib with mefenamic acid. "Our results provide important information about the comparative safety of alternative NSAID use in patients with hypertension in real-world settings. Under low-to-moderate daily dose and a short-term treatment period, most commonly used NSAIDs have similar cardiovascular safety profiles," said co-author Dr. Chia-Hsuin Chang, of the National Taiwan University Hospital.
Source-Eurekalert
Non-aspirin NSAIDs Help Prevent Recurrence of Colorectal Cancer
Non-aspirin NSAIDs (e.g., ibuprofen) work better than aspirin to prevent the recurrence of advanced neoplasia (polyps that are the precursor of colorectal cancer) after polyp removal.
Non-aspirin NSAIDs (e.g., ibuprofen) work better than aspirin to prevent the recurrence of advanced neoplasia (polyps that are the precursor of colorectal cancer) after polyp removal.
Genetic Variations in Individuals Alters Effect of Aspirin, NSAIDs on Colon Cancer
Scientists have found that genetic variations of drugs like aspirin, non-steroidal anti-inflammatory drugs can reduce its impact on treating colorectal cancer.
Scientists have found that genetic variations of drugs like aspirin, non-steroidal anti-inflammatory drugs can reduce its impact on treating colorectal cancer.
Taking NSAIDs With Antithrombotic Therapy Increases Risk of Bleeding, Heart Attack, Stroke, Cardiovascular Death
Treatment with NSAIDs among patients receiving antithrombotic therapy, was associated with an increased risk of bleeding, heart attack, stroke or cardiovascular death.
Treatment with NSAIDs among patients receiving antithrombotic therapy, was associated with an increased risk of bleeding, heart attack, stroke or cardiovascular death.
