Atogepant — A New Hope for Headache Sufferers

Preliminary study found that a specific drug shows promise in preventing migraines in patients who have not found relief with other preventative drugs.

Drug called Atogepant may offer a solution to individuals who have not had success with other preventative drugs for migraines, as per a preliminary study released April 20, 2023, which will be presented at the American Academy of Neurology’s 75th Annual Meeting being held in person in Boston and live online in April 2023.

The study involved people with episodic migraine, which is defined as having up to 14 headache days per month with migraine characteristics.

How Genes are Involved in Migraines?
The relationship between genetic factors influencing blood metabolite levels and migraine risk suggest an alteration of metabolites in people with migraine.

‘Atogepant drug has been discovered to be effective in preventing migraines for individuals who have not responded to other preventative medications, states a new study.’

Atogepant is a calcitonin gene-related peptide receptor antagonist or CGRP inhibitor. CGRP is a protein that plays a key role in starting the migraine process.

Preventing Migraines in Treatment-Resistant Patients

“These results are exciting, as migraine can be debilitating, and this treatment led to fewer days with migraine for people who had already tried up to four other types of drugs to prevent migraine and either had no improvement or had side effects that outweighed any benefits,” said study author Patricia Pozo-Rosich, MD, Ph.D., at Vall d’Hebron University Hospital in Barcelona, Spain.

The study involved 309 people who had at least four migraine days during the month before the study and who had tried at least two classes of drugs for preventing migraine without improvement. Of those, 44% had previously taken three or more classes of preventive drugs with no success.

Transcranial Magnetic Stimulation may Help Treat Stroke, Dementia, and Migraines
Transcranial magnetic stimulation (TMS) can treat a broader range of common neurological conditions, including stroke, acute migraines, and dementia, reveals a new study.

For the study, half of the participants took 60 milligrams of atogepant once a day as a pill and the other half took a placebo for 12 weeks.

Those taking the drug had an average of four fewer days with migraine per month from the start of the study to the end, while those taking the placebo had about two fewer days with migraine per month.

Hormonal Headaches
Headaches can occur due to several causes but normal fluctuations of the female hormones, estrogen and progesterone during the menstrual cycle and perimenopause can trigger severe hormonal headaches and migraines in women.

Those taking the drug also showed improvement compared to those taking the placebo in how often they needed to take medication to stop a migraine attack and in how many people had a reduction of 50% or higher in how many days per month they had migraines.

Migraine Breakthrough!

The most common side effects were constipation, which occurred in 10% of those taking atogepant and 3% of those taking the placebo, and nausea, which occurred in 7% of those taking the drug and 3% of those taking the placebo.

“People who thought they may not find a way to prevent and treat their migraines may have hope of finding relief with a tolerable oral easy-to-use drug,” Pozo-Rosich said. “This treatment was safe, well-tolerated, and effective for people with difficult-to-treat migraine.”

A limitation of the study was the relatively short length of three months. Pozo-Rosich added that more research will be needed to assess the long-term efficacy and safety of atogepant.

Source-Eurekalert