Bacteria That Cause Caries Survive in Dental Plaque

Substances that build extracellular cariogenic bacteria from sugar residue create an environment for bacteria to survive in plaque.

Substances built from sugar residues called extracellular polysaccharides, play a central role in the survival capabilities of caries-causing bacteria in dental plaque, report researchers from the University of Basel's Preventative Dentistry and Oral Microbiology Clinic and Department of Biomedical Engineering in the journal PLOS ONE. //

Cariogenic bacteria live in biofilm and attack dental enamel by converting sugar and starch into acids that dissolve out calcium from the enamel. This process can cause caries.

Tooth Decay - Causes, Symptoms, Diagnosis, Treatment & Prevention
Tooth decay in toddlers, children and adults, also called dental caries, is a bacterial infection causing demineralization and destruction of the hard tissues of the teeth.

‘Cariogenic bacteria develop mechanisms to help them survive the high concentrations of calcium.’

The dissolution of calcium increases the concentration of calcium locally, creating an environment that is hostile to bacterial life. In their study, the researchers investigated how bacteria manage to survive in dental plaque despite these conditions.

They hypothesized that extracellular polysaccharides (EPS) support the bacteria's survival capabilities. EPS are substances that build extracellular cariogenic bacteria from sugar residue. They create the biofilm's scaffolding and ensure that bacteria are able to anchor themselves in the dental plaque.

EPS integrate calcium into the biofilm

Prevent Tooth Decay in Children by Using Dental Sealants
Dental sealants are considered as the quickest, safest and pain-free method to prevent cavities. Dental sealants are also known as pit and fissure sealants.

The study showed that the more calcium cariogenic bacteria dissolve, the greater their calcium tolerance and survival capability in the biofilm becomes. The scientists were able to prove that cariogenic bacteria develop mechanisms to help them survive the high concentrations of calcium.

They demonstrated that extracellular polysaccharides possess a high number of calcium binding sites through which they can integrate the free calcium into the biofilm. This neutralizes the toxic substance and strengthens the EPS structure of the biofilm.

Dental Care for Babies, Toddlers, Preschoolers, Children
Initiating dental care at an early age can prevent tooth decay in children and also helps maintain overall oral health throughout life.

New insights into the causes of caries

The EPS' integration of calcium doesn't just help cariogenic bacteria to survive in dental enamel; it also causes caries. "EPS' integration of calcium inhibits the remineralization of the enamel, as there is no longer sufficient free calcium present in the plaque. This discovery is important in gaining a better understanding of calcium regulation in caries," explains microbiologist Monika Astašov-Frauenhoffer.

Dental Care during Pregnancy
Dental care is not only safe but also essential during pregnancy. Hence, it is important for you to take good care of your teeth while you are pregnant.

Source-Eurekalert