Peptide derived from beetroot inhibited a particular enzyme that is responsible for the breakdown of messenger molecules in the body, revealed a research group.
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Beetroot Peptide Serves as A Potential Drug Candidate For Treating Diseases"
‘Due to its particularly stable molecular structure and pharmacological properties, the beetroot peptide may be a good candidate for development of a drug to treat certain inflammatory diseases, such as e.g. neurodegenerative and autoimmune diseases.
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"By analysing thousands of genomic data, our team was able to define a number of new cysteine-rich peptides and assign them phylogenetically in the plant kingdom. In this process, our attention was drawn to a possible function as so-called 'protease inhibitors'. The beetroot peptide can therefore inhibit enzymes that digest proteins," explains Gruber. 
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The beetroot peptide specifically inhibits prolyl oligopeptidase (POP), which is involved in the breakdown of protein hormones in the body and is therefore able to regulate inflammatory reactions. POP is a much-discussed drug target for neurodegenerative and inflammatory diseases, such as Alzheimer's and multiple sclerosis, for example.
"This means that, in future studies, this group of plant peptides called 'knottins', such as those found in beetroot, could potentially provide a drug candidate for treating these diseases."
Peptide can be detected in commercial beetroot juice
The peptide not only occurs in the root vegetables but can also be detected in commercially available beetroot juice - albeit in very low concentrations. "Although beetroot counts as a very healthy vegetable, it would be unreasonable to hope that dementia could be prevented by regular consumption of beetroot," stresses the MedUni Vienna pharmacologist. "The peptide only occurs in very small quantities and it is not clear whether it can as such be absorbed via the gastrointestinal tract."
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The research work being conducted by Gruber's laboratory utilized the idea of harnessing Nature's blueprint to develop drug candidates. "We are searching through large databases containing genetic information of plants and animals, decoding new types of peptide molecules and studying their structure, aiming to test them pharmacologically on enzymes or cellular receptors (such as one of the prominent drug target classes, the so-called G protein-coupled receptors) and finally analysing them in the disease models," explains Gruber.
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Source-Eurekalert