Scientists understand the link between the evolution of electric fields in enzymes and the development of antibiotic resistances.
Drug Resistance – Antibiotic or Antimicrobial Resistance
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and hospital acquired diseases. Judicious use of antibiotics can control the problem.
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and hospital acquired diseases. Judicious use of antibiotics can control the problem.
‘TEM beta-lactamase enzyme enables bacteria to develop a resistance to antibiotics, such as penicillin and cephalosporins.’
Researchers have been trying to figure out exactly what is happening when an enzyme binds to another molecule and ultimately, how that enzyme becomes resistant to antibiotics. The team of researchers at the Boxer Lab is using an existing technique called the vibrational Stark effect (VSE) in a novel way to measure a molecule's electric field when the enzyme and molecule are attached at different times during the enzyme's evolution to becoming resistant to antibiotics. The team measured the electric fields generated by a TEM beta-lactamase enzyme attached to two different molecules and the vibration of the chemical bonds in these molecules in the hopes that they will find what makes the enzyme develop a resistance to cephalosporins antibiotics.
Source-Eurekalert
Test your Knowledge on Antibiotic Resistance
Antibiotic resistance is a growing public health concern that has reached gigantic proportions. Antibiotic resistance is a change that occurs in bacteria when they are exposed to antibiotics used to treat infections caused by them. This change makes the antibiotics ineffective and the antibiotic-resistant bacteria become “superbugs”.
Antibiotic resistance is a growing public health concern that has reached gigantic proportions. Antibiotic resistance is a change that occurs in bacteria when they are exposed to antibiotics used to treat infections caused by them. This change makes the antibiotics ineffective and the antibiotic-resistant bacteria become “superbugs”.
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