Biological Clock may Have Began Ticking 2.5 Billion Years Ago: Scientist

A biological clock believed to have evolved 2.5 billion years ago was found by an Indian origin scientist and his team.

This discovery may explain exactly how and when life began keeping time.

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Biological clocks are ubiquitous in nature, so the first clock should pre-date the evolutionary parting of the ways that led to modern groups of organisms.

However, all the clocks found so far are unique to different groups of organisms. Not so the clock discovered by Akhilesh Reddy at the University of Cambridge and colleagues.

In an enzyme called peroxiredoxin (PRX), they seem to have found a grandfather clock - one that is common to nearly all life.

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PRX gets rid of poisonous, highly reactive oxygen (ROS), which is produced by oxygen-based metabolism. And the enzyme oscillates: it flits between an active and inactive state, depending on whether oxygen is bound to the active site. Using antibodies that bind only to the oxidised enzyme, the team found that PRX oxidation keeps cycling independently on a 24-hour cycle, even when organisms were kept in constant light or constant dark.

Moreover, they found this PRX cycle in mice, fruit flies, a plant, a fungus, an alga, bacteria and even in archaea - the most primitive of all cellular life.

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That suggests PRX evolved early in life's history. A gene sequence analysis suggests it did so 2.5 billion years ago, during the Great Oxygenation Event (GOE) - a critical interval when the oxygen released by photosynthesis began to accumulate in the atmosphere.

Reddy thinks PRX protected primitive cells from ROS damage by surging when peaks in photosynthesis related to daylight temporarily bumped up levels of oxygen.

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"Initially this was externally driven," New scientist quoted him as saying.

Then PRX began oscillating spontaneously in anticipation of this load - thus becoming an independent daily clock. "Organisms with this anticipatory ability would be better adapted than organisms that merely 'reacted' to things as they happened," Reddy stated.

Because all forms of life appear to dance to the metabolic rhythm of PRX oxidation, Reddy believes it pre-dates the other gene-related clocks that organisms carry.

It may even have driven their evolution. A gene-related clock, unique to cyanobacteria, appears to have evolved alongside PRX. What is more, another archaean that lives without oxygen and never had to deal with ROS has no PRX clock - and no circadian rhythms at all.

When PRX emerged 2.5 billion years ago, the Earth spun faster and a day lasted only 11 hours.

"It will have adapted to the lengthening of the day-night cycle over time," said Reddy.

It may have done more than adapt - day lengths best suited to biological clocks may have coincided with times during which life made important evolutionary leaps.

Ioannis Karafyllidis of the Democritus University of Thrace in Xanthi, Greece, has found that the cycling of the cyanobacterial clock resonates, or works most efficiently, at periods of 11 and 21 hours. These are the day lengths of the GOE and the Cambrian explosion of life, around 530 million years ago.

It would be interesting, Karafyllidis said, to know if PRX - despite adapting to our longer days - has the same intrinsic resonance.

Source-ANI