Blood Pressure Drug Reduces Heart Attack Risk

Telmisartan - a medication used to lower blood pressure - reduces the outcome of cardiovascular death, heart attack or stroke in people who are unable to tolerate a widely available

Telmisartan, a drug, which lowers blood pressure, may also help to reduce the outcome of heart attack or stroke risk in people who are unable to tolerate a widely available and effective standard treatment, according to a research.

ACE inhibitors, or angiotensin-converting-enzyme inhibitors, are widely used and effective medications used to lower blood pressure. They work by helping to widen blood vessels to improve blood flow.

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However, approximately 20 per cent of patients who could benefit from an ACE inhibitor stop taking it because of cough, kidney problems, swelling or symptomatic low blood pressure.

Telmisartan is a type of angiotensin-receptor blocker, or ARB. Like ACE inhibitors, telmisartan also lowers blood pressure, but works in a different manner.

ARBs block the receptor sites in the body for angiotensin II, a naturally occurring hormone that constricts blood vessels and increases blood pressure.

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Blood pressure is the pressure of the blood flowing through your blood vessels against the vessel walls. Just by entering you age, you can get the accurate range of blood pressure value.

For the study, lead authors Dr. Salim Yusuf and Dr. Koon Teo, professors in the Michael G. DeGroote School of Medicine at McMaster University and clinicians at Hamilton Health Sciences, enrolled nearly 6,000 people worldwide who are intolerant to ACE inhibitors, and evaluated whether telmisartan - compared to placebo - would reduce the risk of major cardiovascular events.

A high proportion of patients received proven therapies, such as statins, anti-platelet agents and beta-blockers. Doctors were also free to use other medications that could lower blood pressure.

Heart Attack - Overview
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the leading cause of death in the United States. Other names for heart attack include acute myocardial infarction, coronary thrombosis, and coronary occlusion.

The researchers found that the outcome of cardiovascular death, heart attack or stroke was modestly reduced when patients took telmisartan.

Also, fewer patients receiving telmisartan were hospitalised for any cardiovascular reason compared to placebo.

Animation of heart attack symptoms
Heart attack can cause symptoms such as Chest pain or discomfort, Shortness of breath and pain in neck, back, arm, or shoulder and is due to blockage of blood supply to the heart muscles

Telmisartan was also remarkably well tolerated, and fewer patients on telmisartan discontinued the medication compared to placebo.

It reduced the outcome of cardiovascular death, heart attack, stroke or hospitalization for heart failure by a relative eight per cent (17 per cent in the placebo experienced those cardiac events compared to 15.8 per cent in the telmisartan group). This difference was not statistically significant.

However, when the outcome included cardiovascular death, heart attack or stroke (and not hospitalization for heart failure), telmisartan reduced that outcome by a significant 13 per cent (14.8 per cent in the placebo group experienced those cardiac events compared to 13 per cent with telmisartan).

"The TRANSCEND study demonstrates the value of telmisartan in people who are unable to tolerate angiotensin converting enzyme inhibitors," The Lancet quoted principal investigator Dr. Yusuf, director of the Population Health Research Institute at McMaster University, as saying.

The study is published online by The Lancet and presented at this year's European Society of Cardiology Congress in Munich, Germany.

Source-ANI
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