![Blood Test Helps Predict Who is Likely to Develop Psychotic Disorders Blood Test Helps Predict Who is Likely to Develop Psychotic Disorders](https://images.medindia.net/health-images/1200_1000/agitation-and-psychosis-treatment-in-dementia-patients.jpg)
‘With help from machine learning, analysis of protein levels in blood samples can predict who is at truly at risk of psychotic disorders and could possibly benefit from preventive treatments.’
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The researchers analysed blood samples taken from people at clinical high risk of psychosis. These individuals were followed up for several years to see who did and did not develop a psychotic disorder.Read More..
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After assessing the proteins in blood samples and using machine learning to analyse this data, the scientists were able to find patterns of proteins in the early blood samples that could predict who did and did not develop a psychotic disorder at follow-up.
Many of these proteins are involved in inflammation, suggesting that there are early changes in the immune system in people who go on to develop a psychotic disorder. The findings also suggest that it is possible to predict their outcomes using blood samples taken several years in advance.
The most accurate test was based on the 10 most predictive proteins. It correctly identified those who would go on to develop a psychotic disorder in 93% of high-risk cases, and it correctly identified those who would not in 80% of cases.
"Ideally, we would like to prevent psychotic disorders, but that requires being able to accurately identify who is most at risk," said Professor David Cotter, the study's senior and corresponding author and professor of molecular psychiatry at RCSI.
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A patent application has been filed, and the research team is working to commercialise this research through licensing or partnering with industry.
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Source-Eurekalert