Boffins Identify Protein That Regulate Water Retention in Salt-Sensitive Hypertension

A new research has found that two proteins in the brain act as valves to turn the hormone that regulates water retention in the body.

These findings by the LSU Health Sciences Centre New Orleans may lead to advances in treatment for diseases like high blood pressure, congestive heart failure, and cirrhosis of the liver.

High Blood Pressure
High blood pressure or hypertension is defined as a blood pressure of above 140 mm Hg (systolic) and or 90mm Hg (diastolic).

Daniel Kapusta of the LSU Health Sciences Center and Richard Wainford of LSUHSC reported the role of these brain proteins, called Gaq and Gaz, in producing elevated secretion of the hormone, vasopressin, and water retention in salt-sensitive hypertension, a condition in which blood pressure becomes elevated when salt is consumed.

"Throughout the day, vasopressin, a peptide hormone produced by the hypothalamus, is released into the circulation from the pituitary gland and plays a vital role as the flood-gate keeper to prevent excessive loss of water from the kidneys.

"Under most conditions, the water-retaining action of vasopressin is vital for survival. However, it has remained essentially a black box as to why, in susceptible individuals, the regulatory mechanisms that control vasopressin secretion cannot turn off when the body already has elevated water content," said Kapusta.

High Blood Pressure and Herbs
Drug intervention need not be the only option to help lower your moderately high blood pressure. Lifestyle changes along with herb remedies such as garlic, arjuna, sarpagandha, and olive can serve the purpose.

For 21-days, the research team fed groups of male salt-resistant and salt-sensitive rats a diet containing either normal or high salt.

Then they measured how the treatments influenced the animal's ability to excrete water and how the salt stress altered levels of vasopressin, Gaq and Gaz.

Blood Pressure Chart
Blood pressure is the pressure of the blood flowing through your blood vessels against the vessel walls. Just by entering you age, you can get the accurate range of blood pressure value.

The consumption of high salt triggered a decrease in Gaq proteins in the brain of salt-resistant, but not salt-sensitive, rats.

In salt-sensitive rats, the team demonstrated that reducing brain Gaq proteins returned plasma vasopressin to normal levels, decreased salt-induced water retention, and restored the animal's ability to excrete water.

Binge Drinking Elevates Death Risk in People With Hypertension
If you have high blood pressure, binge drinking may severely increase your risk of dying from a stroke or heart disease.

"Our findings provide evidence that the Gaq sub-unit proteins in the hypothalamus act as a molecular/cellular switch to control the level of vasopressin secretion," said Wainford.

The research was published in the journal Endocrinology.

Source-ANI