Brushing Your Teeth Three Times a Day may Ward Off Diabetes

People who brush their teeth three times a day or more are less likely to develop diabetes, according to a new study. The findings of the study are published in the journal Diabetologia. While the presence of the dental disease is //associated with a 9% increased risk, and many missing teeth (15 or more) are linked to a 21% increased risk. These findings underline the importance of good dental hygiene and are reported in Diabetologia, the journal of the European Association for the Study of Diabetes (EASD).

Inflammation plays an important role in the development of diabetes, a major global health problem. Periodontal disease is also common in the general population. Because periodontal disease and poor oral hygiene can provoke transient infection and systemic inflammation, the authors, including Dr. Tae-Jin Song (Seoul Hospital and Ewha Woman's University College of Medicine, Seoul, South Korea) hypothesized that periodontal disease and oral hygiene indicators would be associated with the occurrence of new-onset diabetes (including both type 1 and type 2 diabetes).

The authors analyzed data collected between 2003 and 2006 on 188,013 subjects from the National Health Insurance System-Health Screening Cohort (NHIS-HEALS) in Korea who had complete data for demographics, past medical history, oral hygiene indicators or laboratory findings. Oral hygiene behaviors (number of tooth brushings, a dental visit for any reason, and professional dental cleaning) were collected as self-reported data from dental health check-ups. The number of missing teeth was ascertained by dentists during examination.

The study found 17.5% (around one in six) of the included subjects had periodontal disease. After a median follow-up of 10 years, diabetes developed in 31,545 people (16%). Using computer modeling, and after adjusting for patient demographics (including age, sex, weight, height, blood pressure, socioeconomic status), physical activity, alcohol consumption, smoking status, vascular risk factors and history of cancer, the presence of periodontal disease and number of missing teeth (15 or more) were both linked to increased risk of developing diabetes by 9% and 21% respectively. Frequent tooth brushing (3 times per day or more) was associated with an 8% decreased risk of developing diabetes.

Further analysis revealed different results for adults aged 51 years and under compared to those 52 years and older. For the younger group, brushing teeth twice a day was linked to a reduced risk of developing diabetes by 10%, and three times by 14%, compared with those who brushed once a day or not at all. In the older group, there were was no difference in diabetes risk between those brushing twice a day and those brushing once a day or not at all, however, brushing three or more times per day compared with once or not at all was associated with a 7% decreased risk.

The periodontal disease appeared to have a stronger effect in younger adults: in the younger group, it was associated with a 14% increased risk of diabetes, while in the older group, the increased risk was 6%. And for adults 51 years and under, having one to seven missing teeth was associated with a 16% increased risk of diabetes, whereas for the older group 52 years and above, having 15 or more missing teeth had the strongest effect, associated with a 34% increased risk of diabetes.

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There were also differences between men and women, with stronger associations between increasing brushing and reduced diabetes risk in women. For women, brushing three times or more per day or twice per day was associated with a 15% and 8% reduction, respectively, of developing diabetes when compared with women brushing once a day or not at all. For men, there was only a 5% reduction in risk of diabetes for those brushing three times or more per day, compared with those brushing once a day or not at all. There was no statistically significant difference in risk between men brushing twice a day and those brushing once a day or not at all.

The authors say that while this study does not reveal the exact mechanism connecting oral hygiene to development of diabetes, they add that tooth decay, especially as it worsens, can contribute to chronic and systemic inflammation, and increase the production and circulation of inflammatory biomarkers, which as previous studies have shown are linked to insulin resistance and development of diabetes.

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They conclude: "Frequent tooth brushing may decrease the risk of new-onset diabetes, and the presence of periodontal disease and increased number of missing teeth may increase that risk. Overall, improving oral hygiene may be associated with a decreased risk of occurrence of new-onset diabetes."

Source-Eurekalert