Calcium Zinc Preconception Lowers Pregnancy Hypertension

Recent research indicates that individuals who consumed higher amounts of calcium and zinc in the three months preceding conception experienced a significantly lower risk of developing hypertensive disorders during pregnancy compared to those with lower intakes of these crucial minerals. These findings underscore the importance of prioritizing nutrition before conception, not just during pregnancy, to support healthy pregnancies ().

“Our findings underscore the significance of preconception dietary intake of calcium and zinc in potentially reducing the risk of hypertensive disorders of pregnancy,” said Liping Lu, MD, PhD, who conducted the research as a postdoctoral research scientist at Columbia University and is now an assistant professor at Ball State University. “Higher intakes of zinc and calcium before conception, derived from diet and supplements, are both associated with a lower risk of hypertensive disorders during pregnancy.”

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Importance of Preconception Nutrition for Healthy Pregnancy

Hypertension, or high blood pressure, is one of the most common disorders of pregnancy and can harm both the pregnant person and the developing fetus. Considering the potential adverse effects of antihypertensive medications during pregnancy, researchers have focused on opportunities to prevent dangerous hypertension-related disorders such as pre-eclampsia through modifiable factors like nutrition.

While many people begin focusing on their nutrition after becoming pregnant, the researchers said that a person’s nutritional status before conception is important since it can often take time for the body to correct deficiencies or imbalances.

“The health of women during the preconception period is strongly linked to the pregnancy outcome,” Lu said. “Adequate nutrient or mineral stores in the body before conception can ensure optimal nutrient status for conception and support the early stages of fetal growth and development.”

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The researchers conducted two separate studies using data from over 7,700 pregnant women across the U.S. who provided information about their health and diet through a study called the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-To-Be. One study focused on calcium while the other focused on zinc. The researchers analysed the association between pre-conception intakes of each mineral and rates of hypertensive disorders of pregnancy after accounting for demographic, lifestyle, and health factors that are also related to the risk of hypertension.

The results showed that people in the highest quintile for pre-conception calcium intake were 24% less likely to experience hypertensive disorders during pregnancy compared with those in the lowest quintile. For zinc, participants were divided into quartiles and those with the highest pre-conception zinc intakes were 38% less likely to experience hypertensive disorders during pregnancy than those with the lowest zinc intakes.

Pregnancy-induced Hypertension Increases Risk of Post-pregnancy Hypertension
Women with pregnancy-induced hypertension are at increased risk of developing post-pregnancy hypertension with associated complications such as heart disease.

As observational studies, Lu noted that the results do not necessarily prove causation. However, the findings align with other studies that have linked higher intakes of the two minerals with a lower risk of hypertension-related diseases outside of pregnancy. In addition, calcium and zinc are both known to play important roles in metabolic processes related to maintaining the health of blood vessels, providing a plausible biological explanation for the notion that these minerals could help to prevent blood pressure disorders.

Recommendations of the National Academies of Sciences, Engineering, and Medicine suggest that women of childbearing age should consume 1,000 milligrams of calcium and 8 milligrams of zinc daily.

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Reference:

NUTRITION 2024: Where the best in science & health meet - (https://nutrition.org/n24/)

Source-Eurekalert