A new clinical trial evaluated the effect of antidepressant medication in treating arthritis chronic pain.

By 2040, an estimated 78 million American adults are projected to have doctor-diagnosed arthritis.
In this new trial, patients experiencing chronic osteoarthritis-related pain in the hip or knee that did not go away with over-the-counter medications, 66 were randomized to duloxetine added to usual care and 66 were randomized to usual care alone.
The trial’s investigators found that duloxetine did not lessen pain at 3 months or 12 months.
However, there was no clinically relevant effect of duloxetine added to usual care compared to usual care alone for chronic osteoarthritis pain, and so it cannot be implemented.
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