Can Preeclampsia During Pregnancy be Caused by the Father?

The occurrence of preeclampsia in a previously fathered pregnancy was more common among the men who had fathered a preeclamptic pregnancy.

The characteristics and lifestyle of the fathers do not play a significant role in their partners’ susceptibility to preeclampsia. This finding is observed in new research published in Acta Obstetricia et Gynecologica Scandinavica.

Preeclampsia that occurs during pregnancy and is characterized by high blood pressure and signs of kidney damage can be dangerous for both mother and baby.

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‘The importance of the father’s genes has been demonstrated in their partners’ susceptibility to preeclampsia, but the role of paternal phenotype and lifestyle is still not well understood.’

The cause of preeclampsia is unclear, making strategies for its prevention challenging, although various maternal risk factors have been recognized.

What Is The Role Of The Father In The Occurrence Of Preeclampsia?

In this new study, researchers examined questionnaire data from 586 men who had fathered a preeclamptic pregnancy and 660 control men who had fathered a non-preeclamptic pregnancy.

Fathers in the former group more often reported preeclampsia in a previously fathered pregnancy, but there were no differences in the socioeconomic background or health history of the preeclamptic and control fathers or their parents.

The groups of fathers reported comparably often having been born from preeclampsia and normal pregnancies, which is in contrast to some previous studies.

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Men who themselves were born in a preeclampsia pregnancy have been shown to have an increased risk of preeclampsia in the pregnancies that they subsequently father.

These findings suggest a role of paternal genes in the increased risk of preeclampsia through the fetal genome. Unfortunately, in the present study, a large number of the fathers did not know whether their mother had preeclampsia.

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It would be of interest to replicate our analyses by utilizing registry-based data, in line with some previous studies. A larger study population would have allowed us to compare the incidence of preeclampsia in previously fathered pregnancies with a different partner than the index mother. Both paternal genotype and phenotype need to be addressed in future studies.

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Source-Medindia