Cardiovascular Mortality Unaffected by Vitamin D, Parathyroid Hormone Levels

There is no link between serum levels of vitamin D or parathyroid hormone and cardiovascular mortality, says a new research.

Researchers collected data from the Rancho Bernardo study, which was established in 1972.

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Between 1997 and 1999, 1091 participants attended a follow-up visit where blood samples were collected, along with detailed surveys of medical history, medications, cigarette smoking, alcohol consumption, and exercise.

In populations with chronic kidney disease, low levels of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and high levels of intact parathyroid hormone have been suggested to explain the association between chronic kidney disease and cardiovascular mortality.

Even in people with intact kidney function, there are multiple mechanisms that could link Vitamin D and cardiovascular disease.

"To our knowledge, this is the first prospective study to investigate the role of serum 25[OH]D, 1,25[OH]2D, and intact parathyroid hormone in the prediction of cardiovascular mortality in a population of older community-dwelling adults with a low prevalence of vitamin D deficiency and a broad range of kidney function," said lead investigator Simerjot K. Jassal, of the University of California.

He continued, "After adjusting for age alone, there was no independent association between serum levels of 25(OH)D, 1,25(OH)2D, or intact parathyroid hormone and cardiovascular mortality."

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"Prior published literature in community-dwelling adults suggests an increased risk of cardiovascular mortality only in individuals with vitamin D levels lower than levels observed here. Our null results may mean that only larger disruptions in levels of 25(OH)D and 1,25(OH)2D contribute to cardiovascular mortality.

"These null findings are also compatible with results from randomized clinical trials in which vitamin D supplementation has failed to prevent cardiovascular outcomes, although the doses of vitamin D in these trials may have been too low," he added.

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The study was published in the American Journal of Medicine.

Source-ANI