CD163 is a macrophage receptor that clears hemoglobin and helps regulate immune responses.
New research offers deeper insight into the body's defence against harmful haemoglobin
Go to source). Scientists were unsure until recently how CD163 works with haptoglobin-hemoglobin (HpHb) to accomplish this task. A recent study published in Nature Communications sheds important light on the molecular mechanisms underlying this process by revealing the precise structure of CD163 linked to HpHb.
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Scientists have completed an old puzzle, which since the 60s from many sides has been regarded as impossible to complete.
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‘Did You Know?
CD163, a macrophage receptor, not only clears hemoglobin-haptoglobin complexes from the blood but also detects bacteria, triggering immune responses. #hemoglobin #haptoglobin #inflammation #medindia ’
CD163, a macrophage receptor, not only clears hemoglobin-haptoglobin complexes from the blood but also detects bacteria, triggering immune responses. #hemoglobin #haptoglobin #inflammation #medindia ’
How CD163 Captures Hemoglobin Complexes
CD163 binds hemoglobin linked to haptoglobin effectively by forming groups of two (dimers) or three (trimers). In order to ensure efficient interaction, researchers discovered that certain acidic residues in CD163 form strong bonds with lysine residues on hemoglobin and haptoglobin.Calcium's function in this relationship is another important discovery. Since calcium is necessary for CD163 activity, the study found calcium-binding sites close to the hemoglobin-haptoglobin interface. These findings shed light on how CD163 prevents harmful accumulation by specifically removing hemoglobin from the circulation.
A Game-Changer for Medicine and Disease Treatment
Comprehending the structure of CD163 has important medicinal implications. Overproduction of free hemoglobin can lead to oxidative damage and inflammation, which can exacerbate conditions like Sepsis, cardiovascular diseases, and Hemolytic Anemia. With this new information, scientists can investigate possible therapies that target CD163 in an effort to enhance hemoglobin clearance and lower inflammation.
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New 'Off Switch' in Immune Response Identified
A new off switch in our immune response has been discovered by Trinity College Dublin researchers.
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- New research offers deeper insight into the body’s defence against harmful haemoglobin -
Source-Eurekalert
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