Innovative, quick, and cost-effective method identifies pneumonia patients who are at risk of respiratory failure or sepsis, reports a new study.
Specific fragments of genetic material were identified, which play a role in the development of respiratory failure and sepsis in pneumonia patients. The findings of the study are presented at the European Respiratory Society International Congress. Presenting the research, Dr. Francisco Sanz said the findings could enable doctors to test quickly for these biological markers when a patient is admitted to hospital with pneumonia so that they could anticipate complications and provide more intensive support and monitoring.
‘Specific fragments of genetic material identified could help doctors to test quickly for the biological markers in patients with pneumonia, and provide more intensive support and monitoring.
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Dr. Sanz, a pulmonologist in the Pulmonary Department at Consorci Hospital Universitari de València and an associate professor at the University of Valencia, and his colleagues analyzed clinical data and blood samples from 169 patients with community-acquired pneumonia - pneumonia acquired outside the hospital or nursing home setting.Read More..
Dr. Sanz said: "Pneumonia is an infection of the lung tissue by viruses or bacteria. The worst complications are the development of respiratory failure and sepsis, which is when the infection spreads via the bloodstream to the rest of the body. There are small molecules called microRNAs, which are fragments of genetic material that regulate how genes behave. We have found that for each type of complication - respiratory failure or sepsis - there is a specific microRNA involved."
The researchers used real-time polymerase chain reaction (PCR) techniques, which is a method used to make copies of small sections of DNA, to identify the microRNAs in the blood samples taken from patients at the time they were admitted to hospital. Then they examined correlations between the microRNAs and sepsis and respiratory failure to see how well certain microRNAs could predict these complications.
They found that three microRNAS that were already known to be involved in lung and systemic inflammatory processes were good at predicting sepsis or respiratory failure. Of the 169 patients, 109 (64.5%) developed complications, with 25.4% developing respiratory failure and 13.6% severe sepsis. MicroRNA 223 was good at predicting the onset of sepsis (78% accurate), and microRNA 574 was good at predicting respiratory failure (77% accurate). MicroRNA 182 was good at predicting both severe sepsis and respiratory failure (with 83% and 76% accuracy, respectively).
Dr. Sanz said: "Our study has improved our understanding of the changes and processes that occur in the body in response to pneumonia by identifying these microRNAs that specifically determine complications, such as sepsis and respiratory failure. This has implications for prognosis. The potential use of these biomarkers would be at the time of admission of patients in order to anticipate the complications that they could develop. Once it was detected that the patient has a certain profile of microRNAs, more intensive support or monitoring measures could be implemented. The test is fast - it takes between one and three hours - and cheap, and it can be performed with techniques that are available in most hospitals."
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Dr. Sanz concluded: "Our study has been conducted in the hospital setting but could be used for outpatients too. In addition, due to the range of ages of the patients in our study, this could be applied to adult patients of all ages, although we cannot extrapolate the results to children."
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"The innovative approach described in this study could provide a quick and cost-effective method for identifying patients at risk of developing sepsis or respiratory failure, which has the potential to save lives and improve patient quality of life, as well as reduce costs for health care providers. However, this test will have to be compared to guidelines and recommended the best clinical practice to confirm its usefulness."
Source-Eurekalert