Colorectal Cancer Detected from a Small Blood Sample by Screening Tool

Early-stage colorectal cancers can be detected by a new microRNA screening, with precision and sensitivity.

"Our test has the potential to be safe, cheap, robust, accurate and of little or no inconvenience to the individual, and could, therefore, easily be integrated into national screening programs as part of an annual checkup," said Søren Jensby Nielsen, Ph.D., scientific manager, Diagnostic Product Development, Exiqon A/S.

Colorectal Cancer - Types, Causes, Risk Factors, Symptoms, Diagnosis, Treatment, Prognosis & Prevention
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third most common cancer in men.

Nielsen presented the results at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development, held here.

"We envision that this type of miRNA profile, once developed and marketed as a screening kit, can be used to screen entire populations in order to facilitate a focused selection of individuals who should undergo colonoscopy," Nielsen said.

Colorectal cancer is the second leading cause of cancer-related deaths in the western world. If diagnosed early, the disease can usually be cured with surgery; however, the prognosis for late-stage cancer is grim. Although several early-detection screening methods are available, "current estimates suggest that less than half of Americans over the age of 50 receive adequate colorectal cancer screening," Nielsen said.

Colo-rectal Cancer - Management
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. Some people require a combination of treatments.

Nielsen's team developed a state of the art screening method based on the miRCURY LNA™ Universal RT microRNA PCR. With it, they profiled blood plasma samples collected from patients with early, resectable (Stage II) colorectal cancer and sex- and age-matched healthy volunteers.

The findings suggested that it is possible to distinguish early-stage colorectal cancer from healthy subjects with good sensitivity and specificity from a single plasma sample — less than 1 mL of blood. Nielsen and colleagues are starting a large, prospective clinical trial in symptomatic individuals undergoing colonoscopy to prospectively validate their screening test.

MicroRNAs Can Be Tumor Suppressors
University of Virginia researchers have discovered that microRNAs, a form of genetic material, can function as tumor suppressors in laboratory studies

Although Nielsen's team focused on colorectal cancer screening, their results indicated the technology has broader applicability. They have used the technology in a project to detect early stage colorectal cancer patients who are likely to experience disease recurrence and, therefore, are candidates for more aggressive adjuvant chemotherapy.

People With Genetic Predictors of Colorectal Cancer are Not Getting Screened
Even when diagnosed with a condition that is a strong genetic predictor of colorectal cancer, many patients do not seek out genetic counseling or cancer screening.

Source-Eurekalert