A particularly deadly form of brain cancer may be warded off by a combination of compounds in marijuana, preliminary research suggests.
A particularly deadly form of brain cancer may be warded off by a combination of compounds in marijuana, preliminary research suggests.
Researchers at the California Pacific Medical Center Research Institute (CPMCRI) combined the non-psychoactive Cannabis compound, cannabidiol (CBD), with 9-tetrahyrdocannabinol (9-THC), the primary psychoactive active ingredient in Cannabis.They found the combination boosts the inhibitory effects of 9-THC on glioblastoma, the most common and aggressive form of brain tumor.
"Our study not only suggests that combining these two compounds creates a synergistic effect but it also helps identify molecular mechanisms at work here, and that may lead to more effective treatments for glioblastoma and potentially other aggressive cancers," said Sean McAllister, a scientist at CPMCRI and the lead author of the study.
Previous studies had shown that 9-THC was effective in inhibiting brain cancer growth in cell cultures and in animal models and prompted a small clinical trial in Spain.
There is also evidence that other compounds in Cannabis might prove effective against tumors, but limited scientific evidence is available.
The CPMCRI researchers screened a number of different cannabis-based compounds before settling on CBD as the most active one.
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The new study has been published in the latest issue of the journal Molecular Cancer Therapeutics.
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TRI