COPD Patients With Moderately Low Blood Oxygen Levels Do Not Benefit From Oxygen Therapy

COPD patients with moderately low blood oxygen levels do not receive the same benefits from long-term oxygen therapy as those with severely low blood O2 levels.

Highlights

An estimated 24 million people in the U.S. suffer from COPD, and it is the third leading cause of death in the nation.
COPD patients with severely low blood oxygen levels benefit from long term oxygen therapy.
But in COPD patients with moderately low blood oxygen levels, no benefit in terms of time of death, first hospitalization or significant quality of life improvements are seen from long-term oxygen therapy.

Chronic obstructive pulmonary disease (COPD) patients with moderately low blood oxygen levels do not benefit from long-term supplemental oxygen treatment.

Long-term supplemental oxygen treatment causes little or no change in time to death, time to first hospitalizations or significant quality of life improvements in COPD patients with moderately low blood oxygen levels.

Chronic Obstructive Pulmonary Disease
COPD includes respiratory tract disorders that cause obstruction to airflow. These are chronic bronchitis, emphysema and small airway disease.

‘The burden and expense of oxygen supplementation therapy and associated risks such as as tipping over the equipment or starting a fire with carrying around heavy and bulky oxygen delivery equipment, can be avoided if the therapy does not benefit COPD patients.’

According to the COPD Foundation, an estimated 24 million people in the U.S. suffer from COPD, and it is the third leading cause of death in the nation. The findings are published in the New England Journal of Medicine.

Oxygen treatment outcomes were measured in 738 COPD patients with moderately low blood oxygen levels at 42 clinical centers across the United States.

The study began in 2009 and ended in 2015.

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Patients who received supplemental oxygen over the course of the study showed no significant differences in rate of hospitalizations, time to death after diagnosis, exercise capacity or quality of life when compared to patients who did not receive supplemental oxygen.

The results of the study show that most people with moderately low blood oxygen levels do not receive the same benefits from long-term oxygen therapy as COPD patients with severely low blood oxygen levels.

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"The benefits of long-term oxygen supplements for COPD patients with severe oxygen deficiency are clear," says Robert Wise, M.D., professor of medicine in the Johns Hopkins University School of Medicine's Division of Pulmonary and Critical Care Medicine and the paper's corresponding author. "However, it's never been established what benefits, if any, exist for patients with less severe oxygen deficiency."

For the study, moderate oxygen deficiency was defined as having a blood oxygen saturation between 89% and 93% at rest, or a blood oxygen saturation below 90% during a six-minute walk test.

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Blood oxygen saturation levels are a measure of oxygen-carrying hemoglobin in circulating blood and a marker of lung function, and low levels are a hallmark of people with COPD.

A normal blood oxygen saturation level is generally defined as between 94% and 99%.

To examine the benefits of supplemental oxygen, the researchers studied two types of COPD patients:

1.those who suffered from moderate oxygen deficiency while resting.

2.those who suffered from moderate oxygen deficiency only during exercise.

Some 133 patients had resting oxygen deficiency, 319 had only exercise-induced oxygen deficiency and 268 had both.

Participants in each of the two groups were randomly assigned to get supplemental oxygen or no supplemental oxygen at the start of the study, and all visited clinics annually for follow-up examinations that included oxygen levels at rest and exercise, oxygen use, respiratory symptoms and quality of life.

All participants also completed telephone interviews biannually and completed mailed questionnaires regarding symptoms and health care use at four and 16 months.

Of the 738 total patients studied with moderate oxygen deficiency, 368 received supplemental oxygen, and 370 did not.

The primary outcomes, time to death or time to first hospitalization, measured were essentially the same in both groups.

The risk of death in the no-oxygen group was 5.7% per year, compared to 5.2% per year for the oxygen group. Overall, the risk of death or hospitalization was not different between the two treatment groups.

"No matter what measure we looked at, it made no apparent difference whether a patient with moderate oxygen deficiency received long-term oxygen treatments or not. I think the evidence is strong and shows that some patients may not need those treatments at all," says Wise.

Wise cautioned that "we don't want to imply that everyone with COPD now using oxygen should stop; some individual patients may find that they can do more activities or have more effective exercise training if they use oxygen. Every patient should discuss his or her specific needs with his or her health care provider, but the data show, very clearly, that for many COPD patients with moderately low blood oxygen levels, supplemental oxygen won't help you live any longer or keep you out of the hospital."

Supplemental oxygen therapy can be considered burdensome and expensive for many. From 2009 to 2011, Medicare reimbursements for oxygen-related costs for COPD patients exceeded $2 billion per year. Supplemental oxygen therapy requires those using it to carry or cart around heavy and bulky oxygen delivery equipment, sometimes resulting in adverse events, such as tripping over equipment or the start of fires.

Source-Medindia