Are you always feeling thirsty and wondering whether it is due to diabetes insipidus or primary polydipsia? Then, Copeptin, a fragment that is cleaved from the antidiuretic hormone (ADH) prohormone helps distinguish between both.
Diabetes Insipidus - Causes, Symptoms, Diagnosis, Treatment, Complications
Diabetes insipidus (DI) is a rare condition where the kidneys cannot retain the appropriate quantity of water.
Diabetes insipidus (DI) is a rare condition where the kidneys cannot retain the appropriate quantity of water.
‘Copeptin, a fragment of the antidiuretic hormone (ADH) or arginine vasopressin prohormone can help distinguish diabetes insipidus from primary polydipsia which is characterized by excessive fluid intake. Copeptin testing is more stable and easier to measure.’
Two diagnostic approaches are the water-deprivation test (with serial measurements of urine and plasma osmolality) and the response to administration of hypertonic saline, but both approaches have limitations. Direct measurement of the response of plasma antidiuretic hormone (ADH, or arginine vasopressin) to provocative testing is potentially helpful, but assays for ADH can be unreliable. Copeptin, a fragment that is cleaved from the ADH prohormone, is more stable and easier to measure.
In this study, researchers studied 141 patients with hypotonic polyuria; ultimately, 58 percent received diagnoses of primary polydipsia, and 42 percent received diagnoses of partial or complete central diabetes insipidus. All patients underwent both water-deprivation and hypertonic-saline testing; plasma copeptin was measured during testing.
Polydipsia (Excessive Thirst) - Symptom Evaluation
Polydipsia or excessive thirst is a symptom commonly associated with conditions like diabetes mellitus, diabetes insipidus or dryness of mouth.
Polydipsia or excessive thirst is a symptom commonly associated with conditions like diabetes mellitus, diabetes insipidus or dryness of mouth.
Source-Medindia
How Much Water Should You Drink in Cold Climates?
Thirst mechanism is weakened at cold temperatures and you need to drink more than what you feel is enough to compensate for the loss of body water that is spent to keep yourself warm.
Thirst mechanism is weakened at cold temperatures and you need to drink more than what you feel is enough to compensate for the loss of body water that is spent to keep yourself warm.
Drinking Soft Drinks to Quench Thirst May Not be Good for Your Kidneys
Drinking soft drinks to rehydrate after heat exposure might aggravate dehydration and kidney damage.
Drinking soft drinks to rehydrate after heat exposure might aggravate dehydration and kidney damage.
