The proofreading exoribonuclease (ExoN) enzyme resists the activity of the antiviral drugs on the SARS-CoV-2 by removing the nucleoside of the drug attached to the virus RNA.
The Exoribonuclease is a proofreading enzyme that checks for mismatched nucleotides on the viral RNA and corrects them by removing them. In the same way, the ExoN enzyme removes the nucleoside analogs of the antiviral drugs and renders the treatment ineffective for diseases like HIV, HCV and Ebola.
Acyclovir for the Treatment of Shingles
Acyclovir is an effective antiviral medication used primarily for treating the symptoms of herpes simplex virus infections, chickenpox, and shingles.
Acyclovir is an effective antiviral medication used primarily for treating the symptoms of herpes simplex virus infections, chickenpox, and shingles.
‘ExoN enzyme acts as a proofreader that recognizes the errors in the virus RNA and corrects them during RNA synthesis.’
SARS-CoV-2 The SARS-CoV-2 is a single stranded RNA virus that causes Covid-19 infection. The genome of SARS-CoV-2 is larger compared to the other viral RNA, it creates a high number of errors during RNA synthesis. The ExoN enzyme proofreads it and corrects it before RNA synthesis. This enzyme is present only in few RNA viruses.
The Covid-19 infection has been declared a pandemic as it has affected many people in more than 180 countries. The virus mainly affects the upper respiratory tract and causes inflammation in the lungs leading to breathing problems. Severe infection can lead to death affecting other major organs like the heart, brain and kidneys. Treatment for this infection has been a challenge because of the presence of the ExoN enzyme which removes the nucleotides of the drugs and replaces it with the viral nucleotides during the translation process (RNA synthesis).
The structure of the ExoN enzyme was published in the Science journal.
Green Fungus or Aspergillosis and COVID-19 Infection
Green fungus or Aspergillosis is caused by a common mold, which exists both indoors and outdoors. Every day, people inhale Aspergillus spores, but it isn't harmful. However, it affects people who have a weak immune system. If the infection is left untreated, it can cause pneumonia.
Green fungus or Aspergillosis is caused by a common mold, which exists both indoors and outdoors. Every day, people inhale Aspergillus spores, but it isn't harmful. However, it affects people who have a weak immune system. If the infection is left untreated, it can cause pneumonia.
The samples of the enzyme are preserved using the cryogenic electron microscopy technique. In this the samples are flash cooled to cryogenic temperatures in vitreous ice.The structure of the enzyme can be studied in detail and new antiviral drugs can be developed against the virus.
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COVID Vaccination for Pregnant Women
The Indian Government has approved Covid-19 vaccination of pregnant women, who are to be counselled and informed regarding the risks and benefits of the vaccines.
The Indian Government has approved Covid-19 vaccination of pregnant women, who are to be counselled and informed regarding the risks and benefits of the vaccines.
Mucormycosis (Black Fungal Disease): A Complication of COVID-19
Mucormycosis is spread by spores from the black fungus, Mycormycetes. It mainly affects people with a weak immune system and attacks the lungs and other organs of the body. It is also known as Black Fungal Disease.
Mucormycosis is spread by spores from the black fungus, Mycormycetes. It mainly affects people with a weak immune system and attacks the lungs and other organs of the body. It is also known as Black Fungal Disease.
