COVID-19 May Have Longer Incubation Period, Study

COVID-19 may have longer incubation period of eight days instead of previous estimates of four to five days. The new, low-cost approach in identifying the incubation period is better as it relies on public database of dates of infection, and uses statistical methods to reduce recall bias.

The incubation period of COVID-19 infection could be as long as eight days, according to a new study that involved assessing many patient samples.

Incubation period is the time from the start of infection to the onset of symptoms. Incubation period for coronavirus was previously thought to be around 4-5 days.

Coronavirus
Coronaviruses infect animals, humans, and birds. Human coronaviruses, such as SARS, MERS, and 2019-nCoV cause respiratory distress and even death. The S protein is the infectious agent of the virus.

‘The new method has accurately measured the average incubation period of COVID-19 infection to be 7.75 days. The more accurate figure for the incubation period, could help make informed guidelines for containment efforts such as quarantines and studies investigating the disease's transmission.’
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According to the scientists, including Chong You from Peking University in China, the previous estimate of smaller incubation period were based on small sample sized, limited data, and self-reports that could be biased by memory or judgement of the patient or interviewer.

The results of the current study is published in the journal Science Advances. The study uses a new, low-cost approach to estimate the incubation periods in infected people who had developed symptoms. This was applied to confirm 1,084 COVID-19 cases in people who had history to travel to Wuhan, or who were residents of Wuhan.

The approach is better as it relies on public database of dates of infection, and uses statistical methods to reduce recall bias.The new approach helped to measure the average incubation period as 7.75 days, with only 10 percent of the patients showing an incubation period of 14.28 days.

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The findings may not apply to later cases in other parts of the world where the virus may have mutated. It may also challenge health authorities who rely on the standard 14-day quarantine.

By providing health authorities with a potentially more accurate figure for the incubation period, the results could inform guidelines for containment efforts such as quarantines and studies investigating the disease's transmission.

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"Countries and health authorities have implemented various containment measures such as quarantines to slow the spread of Covid-19," the Chinese researchers wrote.

“To work effectively, these strategies depend on understanding the disease's incubation period, or the time between someone becoming infected and showing the first symptoms of the disease, and how much it varies from individual to individual," they added.

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Source-Medindia