COVID-19 Vaccine Does Not Increase the Risk of Preterm Birth

New study findings add to the evidence that COVID-19 vaccination is safe during pregnancy.

COVID-19 vaccination during pregnancy does not increase the preterm birth or small-for-gestational-age (SGA) risk, according to the findings reported by the Centers for Disease Control and Prevention (CDC).

Preterm birth (in which babies are delivered earlier than 37 weeks) and SGA (in which babies are delivered smaller in size than normal for the gestational age) have been associated with a higher risk for infant death and disability.

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‘COVID-19 vaccination during pregnancy is not associated with preterm birth or small-for-gestational-age (SGA).’

Pregnant people who contract COVID-19 have an increased risk of disease severity and death, yet only 31% of pregnant people in the United States had received vaccines as of September 2021.

One barrier to vaccine acceptance is the concern that vaccination might disrupt pregnancy.

A new study looked at more than 40,000 pregnant individuals, adds new evidence supporting the safety of COVID-19 vaccination during pregnancy.

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For the study, researchers used data from eight health care organizations participating in Vaccine Safety Datalink, a project established by the CDC to monitor vaccine safety to investigate the risk for preterm birth or SGA among vaccinated and unvaccinated pregnant women aged 16 to 49 years.

Among those included in the study, 10,064 individuals, or nearly 22%, received at least one COVID-19 vaccine dose during pregnancy.

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Most (98.3%) received vaccination during their second or third trimester; the rest (1.7%) received it during their first trimester of pregnancy. Almost 96% of those vaccinated received an mRNA vaccine developed by Pfizer-BioNTech or Moderna.

The study results show that trimester when the vaccination was received, and the number of COVID-19 vaccine doses received were not associated with increased risk of preterm birth or SGA.

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To date, a few studies have described outcomes among live births following COVID-19 vaccination in pregnancy, the researchers say. The new findings add to the evidence that COVID-19 vaccination is safe during pregnancy.

Research into the drivers behind low vaccine acceptance among pregnant people has found that the most common concerns have been a lack of information about COVID-19 vaccine safety in pregnant people and potential harm to the fetus. The results of this study speak to both, said Heather Lipkind, associate professor of obstetrics, gynecology, and reproductive sciences at the Yale School of Medicine and lead author of the study.

Pregnant individuals, in addition to seeing an increased risk of severe disease and death compared with non-pregnant people, are more likely to require admission into the intensive care unit, invasive ventilation, and machine-assisted blood oxygenation.

The CDC and the American College of Obstetricians and Gynecologists recommend the COVID-19 vaccine for people who are pregnant, breastfeeding, trying to get pregnant, or might become pregnant in the future.

Source-Medindia