Curing TB: New Approach may Hold the Key

Scientists at the University of Surrey have come up with a novel approach to analyse metabolic events in bacteria that lead to fatal diseases such as tuberculosis (TB).

The new 'systems biology' approach will help understand the metabolic changes that occur in the bacterium Mycobacterium tuberculosis which allow it to survive dormant in host cells for decades.

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These changes could allow new drugs to be developed against such 'persistent' bacterial cells, which in turn would revolutionise TB control.

Professor Johnjoe McFadden who works on TB at the University of Surrey likens metabolic pathways in cells to Britain's road network.

"For example, we may identify a particular road, say the A45, that takes goods from Birmingham to Coventry and call it the BtoC road - or BtoC gene," he said.

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"Blocking the A45 might be expected to prevent goods from Birmingham reaching Coventry. But of course it doesn't because there are lots of other ways for the goods to get through. In truth, the 'road' (or gene) from BtoC isn't just the A45, but includes all those other routes," he added.

A good starting point to study functional pathways is a mathematical model of the cell that takes into account the system properties of the whole network, rather than focussing on key control points.

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Professor McFadden explains how microbes are well suited to this systems-level approach.

"Microbes have fewer genes to interact with each other making computational modelling simpler. Also, unlike multicellular organisms, microbes are able to precisely control their growth," he said.

"This 'steady-state growth' is an important assumption that mathematical models are based on," he added.

The findings appear in Microbiology Today.

Source-ANI
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