Depression May Speed Up Aging Process in Older Adults

The role of late-life depression (LLD) in poorer physical and cognitive health has been highlighted in a recent study published in the journal Nature Mental Health. They are consonant with the viewpoint that co-occurring medical burdens and their associated disabilities are part of accelerated aging in Late-life depression. Previous studies have demonstrated a strong link between LLD, poor physical health, cognitive impairment, an increased risk for dementia, and mortality.

Why Depression Can Make Older Adults Age Faster?

To look further, researchers from several other institutions looked at 426 people with late-in-life depression. They measured the levels of proteins associated with aging in each person’s blood. When a cell gets old, it begins to function differently, less efficiently, than a “young” cell.

It often produces proteins that promote inflammation or other unhealthy conditions, and those proteins can be measured in the blood. They compared the levels of these proteins with measures of the participants’ physical health, medical problems, brain function, and the severity of their depression.

To their surprise, the severity of a person’s depression seemed unrelated to their level of accelerated aging. However, they did find that accelerated aging was associated with worse cardiovascular health overall.

People with higher levels of aging-associated proteins were more likely to have high blood pressure, high cholesterol, and multiple medical problems. Accelerated aging was also associated with worse performance on tests of brain health such as working memory and other cognitive skills.

Those two findings open opportunities for preventive strategies to reduce the disability associated with major depression in older adults, and to prevent their acceleration of biological aging.

Researchers are now looking at whether therapies to reduce the number of aged cells in a person’s body can improve late-in-life depression. They are also looking at specific sources and patterns of proteins associated with aging, to see if this might lead to personalized treatments in the future.

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Source-Eurekalert