Development Of HIV-1 Vaccine

HIV-1 is a genetically diverse collection of viruses. This makes it a moving target in vaccine development.

In a study published in the Journal of Clinical Investigation, researchers led by Brad Jones at the University of Toronto in investigated the feasibility of eliminating HIV-infected cells by targeting cellular immune responses against a human endogenous retrovirus (HERV). HERVs are the DNA remnants of ancient infectious retroviruses that became part of the germ line cells of our ancestors.

Diabetes and HIV/AIDS Management
HIV/AIDS patients often present with diabetes or other metabolic disorders. The type of diabetes associated with HIV is Type-2 Diabetes Mellitus (T2DM).

Jones and colleagues found that HIV infection stimulated the expression of HERV proteins, effectively tagging HIV-infected cells. Immune cells targeted to these proteins specifically eliminated cells infected with several different strains of HIV in vitro. This study suggests that HERV-targeted immune responses should be considered in the development of HIV vaccines.TITLE:
HERV-K-targeted T-cells eliminate diverse HIV-1/2 and SIV primary isolatesAUTHOR CONTACT:
Brad Jones
University of Toronto, Toronto, ON, CAN
Phone: 617-777-9151; E-mail: [email protected]

Source-Eurekalert

Hives / Urticaria - Symptom Evaluation
Hives are a common result of allergic reactions. In addition, physical factors, systemic diseases and hormonal changes can also result in hives.

Lab Test for AIDS/HIV
Describes how screening for HIV is performed in a laboratory.

AIDS/HIV - Kaposi's sarcoma
Kaposi sarcoma develops below the skin surfaces or in mucous membranes of mouth, nose or anus and appears as lumps