Diabetes and Obesity may Share a Link To Chronic Skin Condition

Metabolic disorders and psoriasis have been linked both genetically and through lifestyle choices, such as smoking, alcohol, levels of physical activity and stress.

Obesity and type 2 diabetes may be associated with inflammatory skin disease such as psoriasis, according to a new study.

Psoriasis is characterized by itchy, rough and red patches on the skin. The disease is persistent and long-lasting. It affects the knees, elbows, palms, and soles of the feet.

Psoriasis can be Triggered by Environmental Factors As Well
One of the known genetic factors involved in psoriasis is CARD14. Mutations in this gene control the expression of several factors that drive skin inflammation.

‘People with psoriasis -a chronic skin disease, may have a greater risk of high body mass index than those without psoriasis.’

The chronic skin condition has been linked to obesity and type 2 diabetes by a team of Danish researchers. This finding is not new because previous studies have found a connection between the three conditions. But, the new research adds more evidence to support the study.

The study involved more than 33,000 twins. The researchers examined the health records of the subjects and found that 4.2% were suffering from psoriasis, 1.4% had diabetes, while 6.3% were obese with a body mass index (BMI) of 30 to 34.

The prevalence of psoriasis among the diabetic subjects was 7.6% compared to 4.1% among individuals without diabetes. The BMI of those individuals was also high who had both diabetes and psoriasis.

Medicare Psoriasis Patients Fail to Continue Long-Term Biologic Treatment
Psoriasis is a common chronic inflammatory disorder, primarily of the skin and its associated with major physical and psychosocial health burdens.

There were 720 twin pairs where one had psoriasis and the other did not. Twins with psoriasis had higher BMI and a higher prevalence of diabetes compared to those who do not have the skin disease.

The researchers believe that similar genetic makeup could be an underlying factor behind the existence of three conditions.

Psoriasis Patients Have Low Adherence to Biologic Drug Therapy
Psoriasis is a common chronic inflammatory disorder, primarily of the skin which has been associated with major physical and psychosocial health burdens.

“Psoriasis is a complex disorder,” said lead researcher Dr. Ann Sophie Lonnberg from the University of Copenhagen. “The genetic background of the disease and its much co-morbidities (co-existing conditions) have not yet been fully uncovered.”

“The reason psoriasis and obesity are associated is not only due to a common lifestyle, but they are also associated due to common genes. It is important to treat psoriasis and obesity and diabetes, since they are risk factors for heart disease and could have serious effects on overall health.”

Onset and Progress of Psoriasis Influenced by Cells in the Skin
Researchers have revealed that different types of dendritic cells in human skin have varied functions in psoriasis.

Source-Medindia