Diabetes Linked to Premature Coronary Heart Disease

Women under 55 with type-2 diabetes had a tenfold greater risk of having coronary heart disease, said researchers.

A new biomarker lipoprotein insulin resistance (LPIR) is associated with a 600 percent increase in the risk of premature coronary heart disease (CHD), said researchers from Brigham and Women's Hospital and the Mayo Clinic. The findings of the study //are published in JAMA Cardiology.

"We're going to see, unfortunately, younger and younger people having heart attacks," said corresponding author Samia Mora, MD, MHS, of the Brigham's Center for Lipid Metabolomics in the Division of Preventive Medicine and an associate professor at Harvard Medical School.

Diabetes and Hypertension: Preventing a Toxic Combination
Diabetes and hypertension (high blood pressure) are significant health problems worldwide, but like cardiac disease and fatty liver disease, people of Indian origin are disproportionately affected.

‘In women, diabetes is associated with premature coronary heart disease. ’

"When a younger individual has a cardiovascular event, it will affect their quality of life going forward, their productivity, and their contribution to society."

"Prevention is better than cure, and many risk factors for heart disease are preventable. This study shows the impact that lifestyle has on heart health in women of all ages, and younger women in particular," said Sagar Dugani, MD, PhD, a hospital internal medicine practitioner at Mayo Clinic in Rochester, MN. Dr. Dugani is a co-first author of the study.

Researchers analyzed more than 50 risk factors in 28,024 women who participated in the decades-long Women's Health Study. Commonly used metrics like bad cholesterol and hemoglobin A1C had much weaker associations with CHD onset in women younger than 55 years than LPIR, a newer metric for insulin resistance.

Test Your Knowledge on Coronary Heart Disease
Coronary heart disease is a direct consequence of today’s unhealthy lifestyle and food habits, which include a high-fat diet, inadequate exercise and loads of stress. Coronary heart disease is emerging as an epidemic of the modern world, affecting younger individuals and extending to poorer countries as well. Here is a quiz that will test your knowledge on basic terminology used in coronary heart disease.

Women under 55 who have obesity had about a fourfold-increased risk for coronary events.

With diabetes prevalence and its associated risk factors increasing dramatically and affecting more women than men, the study emphasizes the urgency of developing effective interventions.

Pregnancy Diabetes Calculator or Gestational Diabetes Calculator
American pregnancy diabetes calculator cautions you about the chance of having diabetes when you are pregnant. Pregnancy Diabetes can affect both the mother and the baby.

Source-Medindia

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