Diabetes, Obesity Treatments may Be Derived from Body Clock-metabolism Link

Researchers at the University of California, Irvine found a molecular link between circadian rhythms, our own body clock, and metabolism - a discovery that will lead to treatments

A molecular link between circadian rhythms, our own body clock, and metabolism has been discovered by researchers at the University of California, Irvine. This discovery may lead to treatments for diabetes, obesity and other related diseases.

Paolo Sassone-Corsi, Distinguished Professor and Chair of Pharmacology, and his colleagues have identified that an essential protein called CLOCK that regulates the body's circadian rhythms, works in balance with another protein called SIRT1 that modulates how much energy a cell uses.

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"This interplay has far-reaching implications for human illness and aging, and it is likely vital for proper metabolism," said Sassone-Corsi, one of the world's leading researchers on circadian rhythms.

The study appears in the July 25 issue of Cell.

Circadian rhythms of 24 hours govern fundamental physiological functions in almost all organisms. The circadian clocks are intrinsic time-tracking systems in our bodies that anticipate environmental changes and adapt themselves to the appropriate time of day.

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Disruption of these rhythms can profoundly influence human health and has been linked to metabolic disorders, insomnia, depression, coronary heart diseases and cancer.

In 2006, Sassone-Corsi identified that the protein CLOCK is an essential molecular gear of the circadian machinery.

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Now, he and his colleagues have shown that the protein SIRT1 counterbalances the function of CLOCK. Even though SIRT1's function differs from CLOCK's, the two proteins interact, creating a bond that is finely regulated in the cell.

SIRT1 senses energy levels in the cell; its activity is modulated by how many nutrients a cell is consuming. It also helps cells resist oxidative and radiation-induced stress, and for this reason SIRT1 is known to help control the process of aging.

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CLOCK and SIRT1 are both part of the epigenome, which consists of proteins existing in connection with a cell's DNA that take external environmental factors and make the cell's genes behave differently, even though those genes do not structurally change.

"When this balance between these two vital proteins is upset, normal cellular function can be disrupted. Because of the role these two enzymes play, changes in our sleep patterns or our diets can directly be translated into how our cells act," said Sassone-Corsi.

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