Diet Matters More in Fighting Hospital-acquired Infection

UNLV research shows promise for role of a high-carbohydrate, low-protein, and low-fat diet in fighting off Clostridium. difficile infections acquired in hospitals.

Diet low in carbohydrates, high in fat and protein can be good for the waistline, but new study shows that just the opposite may help to reduce the hospital-acquired infection caused by Clostridioides difficile. The study appears in mSystems, an open access journal of the American Society for Microbiology.

UNLV scientists found that an interaction between antibiotic use and a high-fat/high-protein diet exacerbate C. diff infections in mice. Conversely, they found that a high-carbohydrate diet - which was correspondingly low in fat and protein - nearly eliminated symptoms.

‘High-carb diet protects against C. diff infection. This suggests that diet may promote microbial groups that can be protective, even after antibiotics.’
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C. diff, an intestinal infection designated as an urgent threat by the U.S. Centers for Disease Control and Prevention, is often acquired when antibiotics have wiped out the "good" bacteria in the gut. Hundreds of thousands of people are diagnosed with C. diff infections each year and more than 10,000 die.

"Every day, we are learning more about the human microbiome and its importance in human health," said Brian Hedlund, a UNLV microbiologist and study co-author.

"The gut microbiome is strongly affected by diet, but the C. diff research community hasn't come to a consensus yet on the effects of diet on its risk or severity. Our study helps address this by testing several diets with very different macronutrient content. That is, the balance of dietary carbohydrate, protein, and fat were very different."

Though studies suggest dietary protein exacerbates C. diff, there's little or no existing research exploring the interaction of a high-fat/high-protein diet with the infection. Hedlund and study co-author Ernesto Abel-Santos, a UNLV biochemist, caution that the study was conducted using an animal model, and more work is underway to begin to establish a link between these diets and infections in people.

"Extreme diets are becoming very popular but we do not know the long-term effects on human health and specifically on the health of the human gut flora," Abel-Santos said. "We have to look at humans to see if it correlates."

Hospital Acquired Infections | Nosocomial Infections - Types, Causes, Symptoms, Risk Factors, Diagnosis, Treatment and Prevention
Hospital acquired infections (HAI) are acquired by patients and health personnel alike in a hospital setting. HAI can be life-threatening and need to be promptly diagnosed and treated. Major causes are bacteria, with fungi and viruses playing a lesser role.

Recent studies suggest that because antibiotics kill bacterial species indiscriminately, the medications decimate populations of organisms that compete for amino acids, leaving C. diff free to propagate.

But Hedlund said the story is even more complex. "It's clear that it's not just a numbers game," he said. The new work suggests that diet may promote microbial groups that can be protective, even after antibiotics. For an infection to flourish, he said, "you might need this combination of wiping out C. diff competitors with antibiotics and then a diet that promotes overgrowth and disease."

The new study raised other questions as well. For example: The high-carb diet, which was protective against C. diff infection, gave rise to the least diverse community of microbes.

"Lots of papers say that a lower microbial diversity is always a bad thing, but in this case, it had the best disease outcome," said Abel-Santos. However, he cautions that a high-carb diet could lead to animals becoming asymptomatic carriers that can disseminate the infection to susceptible subjects.

Source-Eurekalert