Discovery of Chronic Itching Mechanism Leads a Way for Drug Development

The spinal neurons involved in the tingling sensation caused by a light touch are different from those transmitting pain or a 'chemical' itch.

What causes us to itch? A new discovery about the reason for chronic itching may pave way for developing a drug for it, revealed a new study.

Salk Institute researchers have uncovered evidence of a dedicated neural pathway that transmits the itchy feeling triggered by such a light touch.

Scientists Identify Promising Drug Compound for Chronic Itch
'Chronic intractable itch' is a condition where itchy sensation does not easily go away, and it is closely associated with dialysis and renal failure.

Surprisingly, the spinal neurons involved in the tingling sensation caused by a light touch are different from those transmitting pain or a 'chemical' itch, the latter elicited by a mosquito bite or a skin wound that is healing.

The new results lend insights into potential mechanisms of chronic itch, which is caused by a variety of conditions such as eczema, diabetic neuropathy, multiple sclerosis and certain types of cancers. It may also help explain why some people affected by itch are unresponsive to commonly used antihistamine drugs.

"This is the first study that reveals the presence of a dedicated neural pathway for this particular sensation in the spinal cord," says co-senior author Martyn Goulding.

Understanding the Brain Network Underlying the Itch-Scratch Cycle in Chronic Itch Patients
Ongoing scratching an itch can lead to an increase in the intensity of itch as well as pain and permanent skin damage, despite being pleasurable at first.

Overactivation of this pathway, which most likely evolved to detect the presence of disease-bearing insects on the skin, results in increased scratching akin to that seen in patients who develop chronic itch.

The spinal cord contains a variety of neurons called interneurons or "middlemen" that process and relay sensory information from the body including the skin.

Mechanisms in Chronic Itching Unravelled
Scientists have discovered that in chronic itching, neurons that send itch signals also co-opt pain neurons to intensify the itch sensation.

The team found that some of these "middlemen" express a small protein called neuropeptide Y or NPY for short. This neurotransmitter is present throughout the brain and has several functions, but until now, no one knew what NPY neurons did in the spinal cord.

"In the future, maybe we can specifically manipulate or modify the activity of these neurons to help people with chronic itch," Bourane adds. The study is published in the journal Science.

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Source-ANI