A new analysis has found that certain variations in genes that repair DNA can affect a person's risk of developing Hodgkin disease.
A new analysis has found that certain variations in genes that repair DNA can affect a person's risk of developing Hodgkin disease. Published in the April 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that differences in these genes should be further investigated to better understand individuals' susceptibility to this type of cancer.
Proteins that repair damage to DNA are important for maintaining cells' health, particularly for preventing the accumulation of genetic damage that could increase the chances of becoming cancerous. Researchers have found that, in the general population, there are variations in the genes that encode these DNA repair proteins. Research has also shown a link between reduced DNA repair and susceptibility to a variety of cancers, including breast, colon, and lung cancer.
Hodgkins Lymphoma - Incidence Causes Diagnosis Types Treatment FAQs
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by chemotherapy or by radiotherapy.
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by chemotherapy or by radiotherapy.
These five genes are involved in different pathways that repair DNA by performing different modifications to damaged DNA. Changes in these genes can change the make-up and structure of the proteins that carry out these repair processes and therefore could influence how well DNA repair is performed.
The researchers found that variations in DNA repair genes may modify the risk of HD especially when interactions between the pathways are considered. Depending on the variant or combination thereof, people could be, up to four times more likely to develop the disease.
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of subtypes.
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of subtypes.
Source-Eurekalert
SRM
Hodgkin's Lymphoma Child Survivors Face Future Health Risk
People who survived childhood Hodgkin's Lymphoma are at a greater risk of developing second cancer or cardiovascular disease, says a new study.
People who survived childhood Hodgkin's Lymphoma are at a greater risk of developing second cancer or cardiovascular disease, says a new study.
Poorer Patients at Greater Risk of Dying of Non-Hodgkin Lymphoma
Poorer patients are at greater risk of dying of non-Hodgkin lymphoma (NHL) as they could be deprived of chemotherapy.
Poorer patients are at greater risk of dying of non-Hodgkin lymphoma (NHL) as they could be deprived of chemotherapy.
