Do COVID-19 Vaccines and Boosters Protect Pregnant Women from Omicron?

COVID-19 vaccines and boosters protected pregnant women during Omicron surge, suggests a new study. COVID vaccines and first boosters provided significant protection to pregnant women against severe complications and death, even after the arrival of the new Omicron variant, according to a study published in The Lancet medical journal.

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Do COVID-19 Vaccines Protect Pregnant Women?

This study “demonstrates a vaccine effectiveness in preventing complications of severe COVID-19 of 76% following vaccination and at least one booster,” said Dr. Michael Gravett, an OB-GYN with the University of Washington School of Medicine who participated in the study, which was led by Oxford University. “Given the marked increased in maternal mortality and severe morbidity seen in our earlier studies prior to vaccination, the 76% efficacy is pretty impressive and really points to the need to get women vaccinated.”

The main point of the study, which was completed before other variants came on the scene, is for pregnant women to get vaccinated and receive all their boosters, including the bivalent booster, he said.The bivalent booster contains components targeting the original strain of the virus as well as a component of the Omicron strain, which emerged in late 2021.

As of the first week of January, 71% of pregnant women have received their primary COVID vaccines, but only 19% have received the recommended bivalent booster, according to the U.S.Centers for Disease Control and Prevention (CDC). In Washington state, only 29% of pregnant women have received the bivalent booster, Gravett said.

Gravett noted that the study, one of the largest of its kind, compared the outcomes of 1,545 pregnant women diagnosed with COVID-19 with those of 3,073 pregnant women without the infection. UW Medicine sites were one of three in the United States included in the study. Gravett and Dr. Alisa Kachikis guided the Seattle part of the study, which included around 75 women from UW Medical Center-Montlake, UW Medical Center-Northwest, and Harborview Medical Center.

The study was conducted between November 27, 2021, and June 30, 2022, during which time the highly transmissible Omicron strain began to rapidly spread around the world. The study did not include the impact of vaccines and the second booster or the bivalent booster on later mutations of COVID-19.

Vaccinated women were well-protected against severe COVID-19 symptoms and complications and had a very low risk of admission to an intensive care unit, the study found. Full vaccination with a booster conferred the greatest protection, the the researchers noted.

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Effect of COVID-19 Infection During Pregnancy

COVID-19 infection during pregnancy was associated with increased risks of maternal morbidity, severe pregnancy complications, and hospital admission, especially among symptomatic and unvaccinated women. In particular, among unvaccinated women who developed severe COVID-19 symptoms the risk of pre-eclampsia was more than threefold higher than that of women without infection. Obese or overweight women with severe symptoms were at the highest risk for maternal morbidity and severe complications.

Although much of the general population has become less concerned about new variants, pregnant women, especially unvaccinated pregnant women, should not take that attitude, Gravett said.

“If you look at unvaccinated women, you still have an increased death rate, and increased neonatal mortality,” he said. “If you are vaccinated and boosted, especially with a mRNA vaccine, those levels drop by 81%.”

In addition, researchers found no increased risk of vaccine side effects in mothers, fetuses, or newborns and a decreased risk of preterm birth among vaccinated women.

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Let’s Get Vaccinated Against COVID-19

“Bottom line is we need to do a better job for women who may become pregnant, and make sure they receive the vaccines and the bivalent boosters,” he said.

The next study will likely follow up with mothers and babies who received the vaccines and those who did not, Gravett said.

Source-Newswise