ECG Using AI Algorithm can Predict Diabetes and Pre-diabetes Early

An artificial intelligence (AI) algorithm and ECG (electrocardiogram) can accurately predict diabetes and pre-diabetes, reveals a preliminary research published in the online journal BMJ Innovations.// If validated in larger studies, the approach could be used to screen for the disease in low-resource settings, claim the researchers.

An estimated 463 million adults around the world had diabetes in 2019 and picking up the disease in its early stages is key to preventing subsequent serious health problems. However, diagnosis relies heavily on the measurement of blood glucose. This is not only invasive but also challenging to roll out as a mass screening tool in low-resource settings of developing countries, point out the researchers.

How to Diagnose Diabetes Early?

Structural and functional changes in the cardiovascular system occur early on even before indicative blood glucose changes, and these show up on an ECG heart trace.

The researchers, therefore, wanted to see if machine learning (AI) algorithms could be used to harness the screening potential of ECG to predict pre-diabetes and type 2 diabetes in people at high risk of the disease.

They drew on participants who were enrolled in the Diabetes in Sindhi Families in Nagpur (DISFIN) study, that was looking at the genetic basis of type 2 diabetes and other metabolic traits in Sindhi families at high risk of the disease in the city of Nagpur, India.

Families with at least one known case of type 2 diabetes and living in Nagpur, which has a high density of Sindhi people, were enrolled in the study.

Participants provided details of their personal and family medical histories, and their normal diet, and underwent a full range of blood tests and clinical assessments. Their average age was 48 years and 61% of them were women.

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Pre-diabetes and diabetes were identified from the diagnostic criteria specified by the American Diabetes Association.

The prevalence of both type 2 diabetes and pre-diabetes was high: around 30% and 14%, respectively. And the prevalence of insulin resistance was also high—35%---as was the prevalence of other influential coexisting conditions—high blood pressure (51%), obesity (around 40%), and disordered blood fats (36%).

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A standard 12-lead ECG heart trace lasting 10 seconds was done for each of the 1262 participants included. Hundred unique structural and functional features for each lead were combined for each of the 10,461 single heartbeats recorded to generate a predictive algorithm (DiaBeats).

Based on the shape and size of individual heartbeats, the DiaBeats algorithm quickly detected diabetes and prediabetes with an overall accuracy of 97% and a precision of 97%, irrespective of influential factors, such as age, gender, and coexisting metabolic disorders.

Important ECG features consistently matched the known biological triggers underpinning cardiac changes that are typical of diabetes and pre-diabetes.

The researchers acknowledge the study's limitations. Most of the participants in the study were at high risk of diabetes and other metabolic disorders, so unlikely to represent the general population. And DiaBeats was slightly less accurate in those taking prescription medications for diabetes, high blood pressure, high cholesterol and other conditions. Nor were data available for those who became pre-diabetic or diabetic, making it impossible to determine the impact of early screening.

“In theory, our study provides a relatively inexpensive, non-invasive, and accurate alternative [to current diagnostic methods] which can be used as a gatekeeper to effectively detect diabetes and pre-diabetes early in its course.” They conclude and caution .“Nevertheless, adoption of this algorithm into routine practice will need robust validation on external, independent datasets,”



Source-Eurekalert