E.coli’s adaption to temperature especially heat helps explain why certain strains are resistant to certain drugs
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‘Different temperatures had to act as a stressor just as a drug acts as a stressor to a bacterial population. ’
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The work could help doctors administer antibiotics in a more precise way. 
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"I think it's an interesting first step, because if we think about how we treat a patient with an infection, depending on where it is, your body has different temperatures at different locations," says Tina Manzhu Kang, a first co-author of the study. "We found some antibiotics work better with lower temperatures. So that's something you might want to consider when deciding on a treatment."
The team is now looking at how other stressors may have affected E. coli. "There have been a number of other stressors that have been there since the beginning of life, such as pressure. We think the bacteria may have also adapted its resistance to these stressors to help deal with more recent forms of stress, like antibiotics," says Mauricio Cruz-Loya, the paper's other first co-author.
Source-Eurekalert