Aging adults are more likely to have and die from heart disease than their younger counterparts. A new study finds a reason to link biological aging to the development of narrowed, hardened arteries, independent of other risk factors like high cholesterol.
Aging is one of the strongest risk factors for atherosclerosis. A new study determines if vascular aging before the induction of hyperlipidemia enhances atherogenesis. The findings of the study are published in the journal Circulation.// Senior author Daniel Goldstein, M.D., of Michigan Medicine's Frankel Cardiovascular Center, says his team is the first to dissect the biological effect of aging from hyperlipidemia on atherogenesis.
‘Novel therapeutics aimed at improving vascular mitochondrial bioenergetics or decreasing inflammation before hyperlipidemia may reduce age-related atherosclerosis.’
"We identify a novel pathway within the aorta by which mitochondrial dysfunction and the pro-inflammatory cytokine IL-6 co-exist in a positive feedback loop with aging to promote atherosclerosis," Goldstein says of the team's work using mouse models of cardiovascular disease and aging. The researchers report aged mice had more severe atherogenesis than young mice, even when both groups had similar cholesterol levels for the same time period.
Future research, then, might investigate therapies to mitigate against the effects of vascular aging before high cholesterol becomes a problem, with the goal of reducing the development of atherogenesis in the first place, Goldstein and colleagues say.
Source-Eurekalert