Canagliflozin lowered albuminuria with greater proportional reductions in those with moderately and severely increased albuminuria, revealed data.
New Insights into Hypertension Induced Albuminuria Treatment
Latest ESC/ESH guidelines suggested microalbuminuria is related to hypertension-mediated organ damages.
Latest ESC/ESH guidelines suggested microalbuminuria is related to hypertension-mediated organ damages.
‘Canagliflozin lowered albuminuria with greater proportional reductions in those with moderately and severely increased albuminuria.’
Results: After week 13, canagliflozin slowed the annual loss of kidney function across albuminuria subgroups, with greater absolute reductions in participants with severely increased albuminuria (placebo-subtracted difference 3.01 ml/min per 1.73 m2 per year; P heterogeneity<0.001). Heterogeneity for the renal composite outcome of 40% reduction in eGFR, ESKD, or renal-related death was driven by lesser effects in participants with moderately increased albuminuria (P heterogeneity=0.03), but no effect modification was observed when albuminuria was fitted as a continuous variable (P heterogeneity=0.94). Cardiovascular and safety outcomes were mostly consistent across albuminuria levels including increased risks for amputation across albuminuria subgroups (P heterogeneity=0.66). Greater absolute risk reductions in the renal composite outcome were observed in participants with severely increased albuminuria (P heterogeneity=0.004). Conclusions The proportional effects of canagliflozin on renal and cardiovascular outcomes are mostly consistent across patients with different levels of albuminuria, but absolute benefits are greatest among those with severely increased albuminuria.
Source-Medindia
Quiz on Kidney
The kidneys are two bean-shaped organs, each about the size of a fist, and are located just below the rib cage, one on each side of your spine.
Healthy kidneys filter about half a cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. The bladder stores urine. The kidneys, ureters, and bladder are partof the urinary tract.
kidneys remove wastes and extra fluid from your body. Kidneys also remove acid that is produced by the cells of your body and maintain a healthy balance of water, salts, and minerals-such as sodium, calcium, phosphorus and potassium-in your blood ().
Without this balance, nerves, muscles, and other tissues in the body may not work normally.
Kidneys also make hormones that help
The kidneys are two bean-shaped organs, each about the size of a fist, and are located just below the rib cage, one on each side of your spine.
Healthy kidneys filter about half a cup of blood every minute, removing wastes and extra water to make urine. The urine flows from the kidneys to the bladder through two thin tubes of muscle called ureters, one on each side of your bladder. The bladder stores urine. The kidneys, ureters, and bladder are partof the urinary tract.
kidneys remove wastes and extra fluid from your body. Kidneys also remove acid that is produced by the cells of your body and maintain a healthy balance of water, salts, and minerals-such as sodium, calcium, phosphorus and potassium-in your blood ().
Without this balance, nerves, muscles, and other tissues in the body may not work normally.
Kidneys also make hormones that help
- Control your blood pressure
- Make red blood cells
- Keep your bones strong and healthy
Anti-cancer Drugs Have to Ride With Albumin to Get to Cancer Cells
In order to ensure the delivery of the anti-cancer drug, floxuridine is being combined with natural serum albumin, which usually settles around target cancer cells, finds a new study.
In order to ensure the delivery of the anti-cancer drug, floxuridine is being combined with natural serum albumin, which usually settles around target cancer cells, finds a new study.
Canagliflozin
This medication is an antidiabetic (sodium glucose co-transporter 2 (SGLT2) inhibitor), prescribed for type 2 diabetes mellitus along with diet and exercise. For patients with type 2 diabetes along with diabetic kidney disease, physicians should consider using an SGLT2 inhibitor when the eGFR is at or above 30, especially with albuminuria above 300 mg/g, to lower renal and CV risk as per A.D.A recommendations.
This medication is an antidiabetic (sodium glucose co-transporter 2 (SGLT2) inhibitor), prescribed for type 2 diabetes mellitus along with diet and exercise. For patients with type 2 diabetes along with diabetic kidney disease, physicians should consider using an SGLT2 inhibitor when the eGFR is at or above 30, especially with albuminuria above 300 mg/g, to lower renal and CV risk as per A.D.A recommendations.
