Exenatide is a Physiological Option for Diabetes Treatment

Treating Type 2 diabetic patients, especially those who are obese, is a challenging task for any doctor.

According to Dr. Vikas Ahluwalia, President of the Diabetes Care Foundation of India, apart from blood sugar levels, there are several other treatment end points and issues that need to be addressed in such patients.

Diabetes Essentials: Types, Complications, Management & Treatment
Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels and several associated complications if left untreated.

He says that the basic pathophysiology of type 2 diabetes includes three main defects, namely insulin deficiency, excess glucose output and insulin resistance.

Despite the advances in the management of diabetes and development of newer better insulins, there are various unsolved problems in the treatment of obese type 2 diabetic patients as in:

1. HbA1c targets are achieved only in a minority of patients.

Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the demand for medication by 20% and helps you stay healthy.

2. Increase in body weight by most anti-diabetic drugs (insulin, sulfonylureas, glitazones)

3. Weight gain is associated with an increase in blood pressure, LDL, and chronic inflammation as well as decrease in HDL.

Diabetic Diet - Diabetes Mellitus
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nutrients, but low in fat (especially saturated fat) and moderate in calories.

4. Risk of severe hypoglycemia is high in type 2 diabetic with long standing disease.

5. Continuous progression of diabetes deterioration caused by beta cell loss.

Gestational Diabetes About
The condition is not caused by a lack of insulin, but by the action of hormones produced during pregnancy that blocks the action of insulin.

Recently increased evidence from multiple randomized control studies have shown that drugs mimicking the physiological incretin effect on insulin secretion provide better and effective blood sugar control in obese diabetics, Dr Ahluwalia says.

Incretin hormone secretion and actions are impaired in type 2 diabetes. Also beta cell responsiveness to GLP - 1 is reduiced, but exogenous GLP - 1 can still restore beta cell sensitivity to glucose and improve glucose induced insulin secretion.

One such drug called Exenatide (Byetta), which is a synthetic version of salivary protein found in the gila monster, binds to human GLP - 1 receptors on beta cells in vitro. Such incretin based therapies of type 2 diabetes may be expected to reduce hyperglycemia and HbA1c levels, improve alpha cell and beta cell function, improve insulin sensitivity and improve metabolism.

Exenatide is not beneficial for every type 2 duabetic patient. Patient selection is very important before starting exanatide. It is primarily indicated in the following situations:

1. BMI > 30

2. HbA1c > 8.5 on 2/3 antidiabetic drugs

3. not willing for SMBG

4. always feels hungry

5. wants to lose weight

6. anxious about hypoglycemia with insulin.

As with insulin, Exenatide has to be injected subcutaneously once or twice daily. Main side effects include nausea, diarrhea and pancreatitis (0.3 cases in 1000 patients). By Dr. Vikas Ahluwalia

Source-ANI
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