New experiments conducted on mice offer important clues for better treatment of typhoid fever in humans, a recent study has revealed.
New experiments conducted on mice offer important clues for better treatment of typhoid fever in humans, a recent study has revealed. A new model based on transplanting human immune stem cells from umbilicaly cord blood into mice that are susceptible to infections, could pave the way for better treating typhoid fever in humans.
Although mice are normally resistant to the dangerous strain of Salmonella that causes typhoid fever, the bacteria are able to reproduce in the mice that have received transplanted human cells.
The protection conferred by the present inoculation is short-lived, and doesn't have a booster effect, the researchers explained. The oral vaccine spoils easily if storage conditions aren't optimal - as is the case in many tropical countries where typhoid fever is common. It also requires multiple doses. Studies in travelers suggest that many fail to take the vaccine properly.
"The mouse Salmonella infection differs from human typhoid in a number of important respects," said Stephen J. Libby, research associate professor of laboratory medicine.
Fang added that Salmonella typhi, which causes human typhoid fever, has evolved many ways to evade infection-fighting defenses inside humans. It can also enter and destroy disease-fighting cells. The bacteria induce inflammation where it is in their own self-interest, and suppress it when and where it might be a disadvantage, such as in the intestine.
Salmonella has changed over time by acquiring new DNA, such as plasmids and bacteriophages, from other organisms. This borrowed DNA makes it more virulent to humans and other animal hosts.
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The study was reported recently in the Proceedings of the National Academy of Sciences.
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