Father's Diet Could Impact the Long-term Heart Health of His Offspring

Poor low-quality protein in a father's diet may alter the genetic information carried in the sperm, which can have a direct impact on the long-term cardiovascular health of their offspring.

Lack of protein in a father's diet can affect the sperm quality and in turn, could affect the long-term heart health of his offspring, reveals a new study. The findings of the study are published in the Journal of Physiology.

The study carried out by experts from the University of Nottingham's School of Medicine, fed male mice a poor quality low protein diet which impaired the way blood vessels functioned in their offspring, a key indicator of heart disease.

High-protein Diet Does Not Affect Kidney Function
No evidence linking a high-protein diet to kidney disease in healthy individuals or those who are at risk of kidney disease due to conditions such as obesity, hypertension or even type 2 diabetes has been observed.

‘A poor quality paternal low-protein diet may alter the genetic information carried in the sperm. Thus, the health of a father's offspring is affected both by the quality of a father's genetic information passed on within the sperm at conception. ’

Growing evidence indicates maternal diet and well-being at the time of conception can impact on offspring development, often leading to cardiovascular dysfunction and metabolic disease in later life. However, there has been little research into the impact of a father's diet and the effects this can have on the cardiovascular health of his offspring.

This new study bridges this gap in our understanding by using a mouse model to explore the long-term cardiovascular health of offspring from males fed poor quality, low protein diet.

Mice were fed a controlled normal protein diet (18% protein) or low protein (9% protein) diet for a minimum of 7 weeks prior to conception. The results showed that the poor quality diet might have altered the genetic information carried in the sperm, which changed the way blood vessels formed in the developing fetus, and so affected the cardiovascular function in the offspring.

Alzheimer's Could be Delayed By Low Protein Diet: Study
An American study says that a restricted protein diet may delay the process of Alzheimer's disease.

The study also showed that the fluid the sperm is carried in, the seminal plasma, also influenced offspring cardiovascular health.

Dr. Adam Watkins, Assistant Professor in Reproductive Biology, and lead author of the study said: "Our findings indicate that a poor quality paternal low-protein diet may have altered the genetic information carried in the sperm or the composition of the seminal plasma. Our study shows that a father's diet at the time of conception may affect how the blood vessels form, which then leads to permanent changes in how the blood vessels work, resulting in 'programmed cardiovascular ill-health in his offspring.

Liver Damage from a Low Protein Diet can be repaired
A low protein diet led to a 20% reduction in albumin, a protein produced by the liver and an important biomarker of nutritional functionality of the organ.

"These findings are significant for people's health, as it shows that some conditions are attributed to a disturbance in early development processes which can be affected by a father's diet."

This latest research follows on from a previous study by the team published in PNAS, where the team looked at the impact of a low-protein diet on the father's offspring's long-term metabolic health.

Sleep Quality Improves By Losing Weight With a High-Protein Diet
Consuming a lower calorie diet with a higher amount of protein improves sleep quality in middle-age adults.

The study found that males fed a low-protein diet produced sperm with fewer chemical tags on their DNA that regulate gene expression than mice fed a normal diet. Researchers also observed that the seminal plasma suppressed maternal uterine inflammatory and immunological responses, essential for a healthy pregnancy.

Source-Eurekalert