FDA's Diabetes Drug Proves Useful For Multiple Sclerosis Also

University of Illinois researchers have observed that an FDA-approved drug, which is currently in use for diabetes treatment, shows some protective effects in the brains of patients

An FDA-approved drug which is currently used for diabetes treatment has been found to show some protective effects in the brains of patients with relapsing remitting multiple sclerosis, researchers at Illinois opine.

This finding is based on a small, double-blinded clinical trial in which patients with relapsing remitting multiple sclerosis were assigned to take the drug pioglitazone or a placebo.

Multiple sclerosis - Symptoms - Causes - Diagnosis - Treatment
Multiple sclerosis can be a severely disabling autoimmune disease that affects the myelin or insulating layer of the nerve fibers and typically has remissions and relapses

Patients continued their normal course of therapy during the trial.

The researchers initially carried out standard neurological and MRI scans to provide baseline values for lesions typically seen in MS patients.

The patients were evaluated every two months, and blood samples were taken. Repeat MRI scans were done after five months and again after one year.

World Multiple Sclerosis Day - 2009
Multiple sclerosis is a serious neurological disease that can debilitate a person for life

Patients taking the drug showed significantly less loss of grey matter over the course of the one-year trial than patients taking placebo.

Of the 21 patients who finished the study, patients taking the medicine did not show any adverse reactions. They found taking pioglitazone, which is administered in an oral tablet, easy.

Multiple Sclerosis Drug Increases Leukemia Risk, Study Finds
The risk of developing leukemia as a side effect of a drug for multiple sclerosis (MS) is higher than previously reported, according to a study to be presented as part of the Late-breaking

"This is very encouraging. Grey matter in the brain is the part that is rich in neurons. These preliminary results suggest that the drug has important effects on neuronal survival," said Douglas Feinstein, research professor of anesthesiology at UIC.

The researchers revealed that they focused on pioglitazone because of its known anti-inflammatory effects.

Adding Steroid to Multiple Sclerosis Drug May Reduce Disease Activity
Using a steroid drug for multiple sclerosis (MS) in addition to an MS drug may reduce the amount of disease activity more than using the MS drug alone.

They used primary cultures of brain cells to show that pioglitazone reduced the production of toxic chemicals called cytokines and reactive oxygen species, the molecules that are believed to be important in the development of symptoms in MS.

Feinstein's lab has shown that pioglitazone and other TZDs "can significantly reduce the clinical signs in mice with an MS-type disease."

"More importantly, when mice who are already ill are treated with pioglitazone, the clinical signs of the disease go away. We were able to induce almost complete remissions in a number of mice," he said.

"We are now working to determine the mechanisms to explain the protective effect on neurons that we see in our studies. We hope to expand into a larger trial to confirm these preliminary results," he added.

The study has been published in the online edition of the Journal of Neuroimmunology.

Source-ANI
TAN