First Case Bone Tissue Death Reversed

For the first time doctors have successfully reversed a case of early-stage avascular necrosis -- death of bone tissue.

For the first time doctors have successfully reversed a case of early-stage avascular necrosis — death of bone tissue.

This reversal has been achieved for the first time in the world by anticoagulant Rivaroxaban, prescribed orally, Moolchand Medcity said in a statement on Tuesday.

Avascular Necrosis | Osteonecrosis - Sites Causes Clinical features Treatment FAQs
Avascular necrosis or Osteonecrosis affects the bone and occurs because of the interruption to its blood supply resulting in bone death and leading to secondary osteoarthritis.

‘Avascular necrosis (AVN) is the death of bone tissue due to a lack of blood supply. Also called osteonecrosis, it can lead to tiny breaks in the bone and the bone's eventual collapse.’

Doctors at the hospital were presented with a 56-year-old woman with pain in the left hip joint and groin, even during rest. The pain aggravated while walking, which also resulted in limping.

She also hypertension, Type-2 diabetes mellitus, dyslipidemia — high cholesterol levels — and obesity.

On examination, there was restricted movement and range of motion in the left hip joint with no history of fever or trauma. The ESR, CRP, and anti-CCP antibodies were normal.

Long-term Monitoring Helps Maintain Bone Health in Childhood Cancer Survivors
Chemotherapy and radiation can have long-term effects on bone health, impacting the attainment of peak bone mass, predisposing to premature low bone mineral density, impairment of bone quality or avascular necrosis of bone.

The diagnosis revealed early AVN of the hip joint.

Anticoagulants such as enoxaparin had been used in the past to prevent the progression of osteonecrosis.

District Hospital in Jammu Conducts First Hip Joint Replacement Surgery
Dr. Balvinder Singh, a former orthopedic faculty at Delhi's Safdarjung Hospital conducted the surgery for the 23-year-old Azhar to treat avascular necrosis.

But the team of doctors prescribed oral blood thinner (anticoagulant) Rivaroxaban 10 mg daily with other symptomatic treatment.

"After treatment for one month, she had a significant decrease in symptoms and started to walk without assistance," said doctors led by Dr. H.K. Chopra from the hospital.

Alcohol And Steroid Supplements Linked To Hip Loss Among Young Population In India
Almost 50 percent of hip replacement surgeries is a trend that is on the rise among India's young population that is due to avascular necrosis.

A repeat MRI pelvis after three months of treatment surprisingly showed no abnormality in the hip joint at all suggesting thereby complete recovery.

"Another MRI was done after six months which showed sustained recovery indicating remarkable successful reperfusion of jeopardised head of the femur with complete recovery from AVN which is a revolution," Chopra said.

Source-IANS