US regulatory has approved the first human clinical trial using the breakthrough gene editing technique, CRISPR/Cas9.
A Guide to CRISPR Gene Activation by Wyss Institute
The CRISPR-Cas9 system has come to be known as the quintessential tool that allows researchers to edit the DNA sequences of many organisms and cell types.
The CRISPR-Cas9 system has come to be known as the quintessential tool that allows researchers to edit the DNA sequences of many organisms and cell types.
‘National Institutes of Health (NIH) has approved the first-in-human use of the gene editing technology CRISPR for the treatment of three types of cancer: myeloma, melanoma and sarcoma.’
The National Institute of Health's (NIH) Recombinant DNA research advisory committee (RAC) has accepted the proposal of using CRISPR to treat patients with three types of cancer namely myeloma, melanoma, and sarcoma. Scientists at the University of Pennsylvania along with MD Anderson Cancer Center in Houston and the University of California at San Francisco will conduct the first early stage trial on 15 cancer patients.
According to the researchers, CRISPR/Cas9 technique will be used to edit genes in T cells, the immune cells. First, CRISPR edit will insert a protein engineered to detect cancer cells and instruct the T cells to target them. Next, the protein that could interfere with this process will be removed. Finally, the edit will prevent the cancer cells from disabling the T cells by removing the gene which identifies the T cells as immune cells.
Gene-Editing Tool - CRISPR/Cas9 Made More User-Friendly by Indian-American Researchers
CRISPR/Cas9 is a tool that can target a particular segment of DNA in cells, such as a gene mutation, and replace it with a genetic sequence.
CRISPR/Cas9 is a tool that can target a particular segment of DNA in cells, such as a gene mutation, and replace it with a genetic sequence.
Source-Medindia
Antibiotic Resistance may be Promoted by CRISPR System
Antibiotic resistance in Francisella novicida, a close relative of a bacterium that causes tularemia, is promoted by a system of genes that bacteria use to fend off viruses
Antibiotic resistance in Francisella novicida, a close relative of a bacterium that causes tularemia, is promoted by a system of genes that bacteria use to fend off viruses
New Method Makes Genome Editing Easier in Mice
The new method, called CRISPR-EZ (CRISPR RNP electroporation of zygotes) uses a jolt of electricity to create holes in the embryos through which molecules can enter.
The new method, called CRISPR-EZ (CRISPR RNP electroporation of zygotes) uses a jolt of electricity to create holes in the embryos through which molecules can enter.
